Hydrogel Particle-Based microRNA Profiling for Discovery and Cancer Diagnostics

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 2R44CA141980-02A1
Agency Tracking Number: R44CA141980
Amount: $2,000,001.00
Phase: Phase II
Program: SBIR
Solicitation Topic Code: NCI
Solicitation Number: PA10-050
Timeline
Solicitation Year: 2011
Award Year: 2011
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
1 KENDALL SQ BLG 1400W FL 3, CAMBRIDGE, MA, 02139-1929
DUNS: 828298195
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 DANIEL PREGIBON
 (857) 998-0421
 pregibon@gmail.com
Business Contact
 DANIEL PREGIBON
Phone: (857) 998-0421
Email: pregibon@gmail.com
Research Institution
 Stub
Abstract
DESCRIPTION (provided by applicant): MicroRNA targets have shown enormous potential for understanding, diagnosing, and even treating the world's most prevalent diseases including cancer, heart disease, Alzheimer's, diabetes and many more. Unfortunately, miRNAs are particularly challenging to quantify due to their small size, sequence homology, and wide range of abundance. As such, miRNA profiling is either expensive or low-throughput using today's state-of-the art technologies. To overcome these limitations, a new multiplexing technology built on encoded hydrogel microparticles and a custom microRNA labeling scheme will be scaled up, automated, and validated. This project could have implications in cancer research, drug discovery, and cancer diagnostics.PUBLIC HEALTH RELEVANCE: The aim of this project is to develop a technology capable of profiling across all human microRNA in a manner that is accurate, rapid, and inexpensive. This tool will be enabling for cancer research, drug discovery, and cancerdiagnostics.

* Information listed above is at the time of submission. *

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