Controlling Inflammation Due to Cardiac Devices

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 4R44HL099015-02
Agency Tracking Number: R44HL099015
Amount: $1,352,967.00
Phase: Phase II
Program: SBIR
Awards Year: 2011
Solicitation Year: 2011
Solicitation Topic Code: NHLBI
Solicitation Number: PA09-080
Small Business Information
NOVELMED THERAPEUTICS, INC.
2265 ENTERPRISE PKWY, TWINSBURG, OH, 44087-2337
DUNS: 190155171
HUBZone Owned: N
Woman Owned: Y
Socially and Economically Disadvantaged: N
Principal Investigator
 REKHA BANSAL
 (440) 477-9874
 rekha@novelmed.com
Business Contact
 REKHA BANSAL
Phone: (216) 707-1776
Email: rekha@novelmed.com
Research Institution
 Stub
Abstract
DESCRIPTION (provided by applicant): NovelMed's lead drug candidate prevents biomaterials induced cellular activation. Activated cells release inflammatory mediators that are responsible for pathological trauma that leads to cardiac, lung, liver, and braininjuries during surgical procedures that require cardiac devices. Our findings provide convincing support for developing YalcixiMab as a treatment to prevent biomaterial-induced inflammation that occurs during surgical procedures. CPB circuits are used during various procedures for heart transplant, and valve replacements. Treatment of blood with YalcioMab prior to the extracorporeal circulation prevents complement activation, neutrophil activation, monocyte activation, platelet activation and the formation of leukocyte-platelet aggregates. The drug also prevents the release of potent inflammatory mediators such as TNF-1. . PUBLIC HEALTH RELEVANCE: NovelMed is developing treatments that will reduce/prevent complications that arise when blood is exposed to biomaterial surfaces of the cardiac devices. Cardiopulmonary bypass circuits are utilized in several cardiac surgeries as a heart-lung machine while surgeons perform procedures on the empty heart. The ultimate objective of this proposal is the development of technologies that will improve the manufacturing of engineered human tissues

* information listed above is at the time of submission.

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