System for guided imaging and characterization of neural circuits

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$754,477.00
Award Year:
2011
Program:
SBIR
Phase:
Phase II
Contract:
2R44MH083352-02
Award Id:
n/a
Agency Tracking Number:
R44MH083352
Solicitation Year:
2011
Solicitation Topic Code:
NIMH
Solicitation Number:
PA10-050
Small Business Information
185 ALLEN BROOK LN, STE 201, WILLISTON, VT, -
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
787008242
Principal Investigator:
JACOBGLASER
(802) 288-9290
jack@mbfbioscience.com
Business Contact:
JACOBGLASER
(802) 288-9290
jack@mbfbioscience.com
Research Institute:
Stub




Abstract
DESCRIPTION (provided by applicant): We propose the Radial Scanning Objective (RSO), an innovative microscope objective that permits simultaneous automated neuron reconstruction using guided image collection, cell electrophysiological recording, and cell loading in live tissue. The RSO device will allow precise, accurate imaging by moving the objective lens relative to the tissue under study, without the need to move the electrodes, the tissue chamber, or the microscope itself. The RSO device and accompanying software technology will be the first commercially available product to a) enable direct recording of single distal synaptic connections formed between different areas, b) facilitate repeated monitoring of potential alterations in neuronal morphology during or as a result of stimulation, and c) permit simultaneous recording of one or more neurons formed between different areas in brain slices identified based on neuronal structure. This system will allow significant advancements in integrated studiesof neural function and structure in basic neuroscience as well as in neurotoxicology and pharmacological research and development, representing clear progress beyond the state-of-the-art. PUBLIC HEALTH RELEVANCE: The proposed project will enable important new studies in neuroscience research that are not currently feasible. This project commercializes an innovative microscope hardware device and software combining the capabilities of guided automated neuron reconstruction, cell electrophysiological recording and cell filling in live tissue that will allow researchers to more accurately identify cells within a neural circuit, even those located at a distance from the original cell. The new device allows precise, accurate imaging by moving the objective lens relative to the tissue under study, without the need to move the electrodes, the tissue chamber, or the microscope itself. The overall effect of this project will open new horizons in integrated studies of neural function and structure in basicneuroscience as well as in neurotoxicology and pharmacological research and development and related fields involving research in neurological disease.

* information listed above is at the time of submission.

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