Efficacy of Light-Activated Anti-Microbial Fabrics against Human Pathogens

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$100,000.00
Award Year:
2011
Program:
SBIR
Phase:
Phase I
Contract:
1R43OH009692-01A1
Agency Tracking Number:
R43OH009692
Solicitation Year:
2011
Solicitation Topic Code:
NIOSH
Solicitation Number:
PA09-080
Small Business Information
LAAMSCIENCE, INC.
633 Davis Dr., Suite 400, MORRISVILLE, NC, 27560-6884
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
623135964
Principal Investigator:
JOSEF SCHNEIDER
(919) 655-0414
patrick.mize@laamscience.com
Business Contact:
JOSEF SCHNEIDER
(919) 655-0414
patrick.mize@laamscience.com
Research Institution:
Stub




Abstract
DESCRIPTION (provided by applicant): Project Summary/Abstract The Specific Aim of this proposal is to test the efficacy of Light-Activated Anti-Microbial fabrics to biologically inactivate three model pathogens, influenza H1N1 swine, respiratory syncytial virus (RSV) and cowpox virus (as a surrogate for variola virus). These viruses are pathogenic to humans and spread rapidly from infected to uninfected individuals. The World Health Organization estimates that influenza epidemics cost the US economy 71-167 billion per year and that 250,000-500,000 people die every year from influenza. RSV poses a severe and continual health risk to children and the elderly, especially in a hospital setting. Variola virus, although eradicated in the general population since 1977, still poses a deadly threat as a bioterrorism agent. Prevention of the spread of infectious viruses is largely accomplished through isolation of infected patients away from the general population. The use of personal protective equipment (PPE), such as respirator masks and gloves, is currently the most effective way that health care workers can protect themselves. However standard contaminated PPE also can serve as effective modes of microorganism transmission when worn by health care workers treating multiple patients. Using a proprietary technology, LaamScience has developed coatings for a durable, self-decontaminating, and cost-effective N95 respirator mask that inactivate a broad spectrum of enveloped viruses and bacteria. The coating containsa Light-Activated Anti-Microbial (LAAM) dye that emits a reactive oxygen species, singlet oxygen, when exposed to light. Singlet oxygen is highly effective at inactivating viruses and killing bacteria. We have shown efficacy against influenza virus strainsas well as staphylococci under normal room light conditions, with inactivation measured in minutes rather than the hours required with traditional antimicrobial agents. The proposed Phase I work will address the potential of the LaamScience coated fabricto inactivate Influenza, RSV and cowpox virus, as evidence to support the use of coated masks in healthcare settings, and more generally in the event of the release of a bioterrorism agent. The milestones of this work are to demonstrate the ability of theanti-microbial to inactivate cowpox virus (as a model for smallpox), Influenza H1N1 swine, and RSV. We will confirm that the virus inactivation is irreversible and occurs in a practical window of time under indoor lighting conditions. Accomplishment of these milestones will allow testing of real-world applications of the fabric coating against these viruses as well as against additional pathogens, which will be the goal of the Phase II studies. PUBLIC HEALTH RELEVANCE: Project Narrative - PublicHealth Relevance The World Health Organization estimates that influenza epidemics cost the US economy 71-167 billion per year and that 250,000-500,000 people die every year from influenza. Groups most at risk are health care workers, patients, young people, and the geriatric population. In closed settings, (e.g., hospitals, child-care centers, military barracks, college dormitories, nursing homes) infections spread rapidly. Viral threats also include intentional spreading of deadly viruses, such as smallpox, as bioterrorism agents. Thus, new, multiple measures are needed to decrease infection rates and protect against bioterrorism threats. The LaamScience fabric coating will serve as a decontamination agent on personal protective equipment such as respirator masks and will reduce the danger of transmission of pathogenic agents between individuals.

* information listed above is at the time of submission.

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