TAS::75 0849::TAS

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$186,857.00
Award Year:
2011
Program:
SBIR
Phase:
Phase I
Contract:
N43CO110037
Award Id:
n/a
Agency Tracking Number:
N43CO110037
Solicitation Year:
2011
Solicitation Topic Code:
NCI
Solicitation Number:
n/a
Small Business Information
52623 SEVEN OAKS DR, SHELBY TOWNSHIP, MI, 48316-2990
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
968109702
Principal Investigator:
JIAJIU SHAW
(313) 874-6798
JIAJIUSHAW@GMAIL.COM
Business Contact:
JIAJIU SHAW
(313) 874-6798
JIAJIUSHAW@GMAIL.COM
Research Institute:
Stub




Abstract
Radiotherapy can potentially inflict serious damage on healthy normal organs. For example, pneumonitis and fibrosis are two well-recognized adverse effects from lung cancer radiotherapy: Currently, amifostine (Ethyol) is the only approved radioprotector indicated to reduce xerostomia associated with radiotherapy of head-and-neck cancer; there is no data supporting the radioprotection by amifostine. Several clinical studies indicated that TNF-61537; biologics may be effective in treating radiation pneumonitis. However, biologics are inconvenient to administer, and have been reported to be associated with potentially serious side effects. In this proposal, a small-molecule TNF-61537; modulator, UTL-5g, will be investigated for its potential to treat lung injury induced by radiation. The specific aims are: (1) To examine whether tumor cell-killing by irradiation is reduced by UTL-5g in vitro; (2) To show that UTL-5g is effective in reducing lung injury induced by irradiation in a dose-dependent manner in vivo; (3)To show that UTL-5g does not affect tumor cell-killing induced by irradiation in vivo. Successful completion of this study will prove the feasibility of using UTL-5g for treating radiation-induced lung injury. The ultimate goal of this project is to workwith or license to a major pharmaceutical company and develop a significantly improved radioprotector for lung radiotherapy.

* information listed above is at the time of submission.

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