SBIR TOPIC 306 - DEVELOPMENT OF INNOVATIVE ALGORITHMS/SOFTWARE FOR PROCESSING and ANALYSIS OF IN VIVO IMAGES IN ONCOLOGY

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$198,131.00
Award Year:
2011
Program:
SBIR
Phase:
Phase I
Contract:
N43CO110042
Award Id:
n/a
Agency Tracking Number:
N43CO110042
Solicitation Year:
2011
Solicitation Topic Code:
NCI
Solicitation Number:
n/a
Small Business Information
11001 SUGARBUSH TER, ROCKVILLE, MD, 20852-3240
Hubzone Owned:
N
Minority Owned:
Y
Woman Owned:
N
Duns:
556593791
Principal Investigator:
JASONGENG, PH.D.
(301) 637-6828
XIGENLLC@GMAIL.COM
Business Contact:
JASONGENG, PH.D.
(301) 637-6828
XIGENLLC@GMAIL.COM
Research Institute:
Stub




Abstract
In this SBIR, Xigen proposes to develop a set of novel 3D registration algorithms and a software package for image-guided radiotherapy (IGRT). This novel software synergistically correlates cone-beam computed tomography (CBCT) phase-binned (or amplitude-binned) volumetric 3D images with real-time optical 3D (O3D) surface images to provide in-vivo accurate volumetric 3D location of the treatment target and surrounding anatomy of the patient in the treatment position in (near) real-time. CBCT can provide volumetric 3D/4D images of patients anatomy prior to an IGRT session. However, due to acquisition speed and radiation exposure, CBCT is not suitable for continuous use in real-time patient monitoring. In contrast, optical 3D surface imaging can be performedin-vivo and continuously without any ionizing radiation. It however is not able to provide internal anatomy information. The innovative approach proposed herein inherits advantages of both the CBCT and the optical 3D surface imaging, while alleviating drawbacks of both. It promises to provide viable in-vivo solution to IGRT for significantly reducing errors in all three stages of radiation therapy (RT): (1) treatment planning; (2) patient setup for treatment; and (3) adaptation to inter-fractional anatomicchanges and intra-fractional movement. To the best of Xigen's knowledge, there is no existing technology that can achieve similar performance of real-time surface-volumetric 3D imaging for IGRT.

* information listed above is at the time of submission.

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