RandD-OTHER SCIENCES-B RES

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$199,834.00
Award Year:
2011
Program:
SBIR
Phase:
Phase I
Contract:
N43CO110054
Award Id:
n/a
Agency Tracking Number:
N43CO110054
Solicitation Year:
2011
Solicitation Topic Code:
NCI
Solicitation Number:
n/a
Small Business Information
4201 Branchwood Dr, Durham, NC, 27705
Hubzone Owned:
N
Minority Owned:
Y
Woman Owned:
N
Duns:
962735374
Principal Investigator:
ANIL GOYAL
(919) 593-6230
ANIL@QUALIBERINC.COM
Business Contact:
ANIL GOYAL
(919) 593-6230
ANIL@QUALIBERINC.COM
Research Institution:
Stub




Abstract
Gemcitabine (Gemzar) is an effective chemotherapeutic drug approved for treatment of several cancers, including non-small cell lung cancer (NSCLC), pancreatic, breast and ovarian cancer. However, its use has been limited due to its short half-life and significant systemic toxicity. This proposal utilizes a novel Lipid-Calcium-Phosphate (LCP) nanoparticle platform for the design of multifunctional targeted nanoparticles (NP) to deliver gemcitabine triphosphate (GTP) and 111Indium to cancer cells. In these novel particles GTP is a therapeutic agent and 111Indium is a radio-imaging agent. These resulting LCP-GTP-Indium theranostic nanoparticles will be evaluated for efficacy in lung tumor models and imaging capabilities. The novel NPs will also be evaluated forpreliminary toxicity in normal mice. The targeted LCP-GTP-Indium theranostic nanoparticles are expected to increase the half-fife and lower the toxicity of gemcitabine while simultaneously allowing for tumor imaging capabilities. Development of GTP+lndiumnanoparticles will improve the delivery of a known chemotherapy drug and enhance the potential for expanded use of this drug in lung and other cancers. Furthermore 111Indium will allow in vivo tracking and imaging of NP without affecting the NP characteristics or biodistribution. This diagnostic capability will enable individualized treatment based on biodistribution, leading to a true personalized medicine product.

* information listed above is at the time of submission.

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