RandD-OTHER SCIENCES-B RES

Award Information
Agency:
Department of Health and Human Services
Amount:
$199,834.00
Program:
SBIR
Contract:
N43CO110054
Solitcitation Year:
2011
Solicitation Number:
N/A
Branch:
N/A
Award Year:
2011
Phase:
Phase I
Agency Tracking Number:
N43CO110054
Solicitation Topic Code:
NCI
Small Business Information
QUALIBER, INC.
4201 Branchwood Dr, Durham, NC, 27705
Hubzone Owned:
N
Woman Owned:
N
Socially and Economically Disadvantaged:
Y
Duns:
962735374
Principal Investigator
 ANIL GOYAL
 (919) 593-6230
 ANIL@QUALIBERINC.COM
Business Contact
 ANIL GOYAL
Phone: (919) 593-6230
Email: ANIL@QUALIBERINC.COM
Research Institution
 Stub
Abstract
Gemcitabine (Gemzar) is an effective chemotherapeutic drug approved for treatment of several cancers, including non-small cell lung cancer (NSCLC), pancreatic, breast and ovarian cancer. However, its use has been limited due to its short half-life and significant systemic toxicity. This proposal utilizes a novel Lipid-Calcium-Phosphate (LCP) nanoparticle platform for the design of multifunctional targeted nanoparticles (NP) to deliver gemcitabine triphosphate (GTP) and 111Indium to cancer cells. In these novel particles GTP is a therapeutic agent and 111Indium is a radio-imaging agent. These resulting LCP-GTP-Indium theranostic nanoparticles will be evaluated for efficacy in lung tumor models and imaging capabilities. The novel NPs will also be evaluated forpreliminary toxicity in normal mice. The targeted LCP-GTP-Indium theranostic nanoparticles are expected to increase the half-fife and lower the toxicity of gemcitabine while simultaneously allowing for tumor imaging capabilities. Development of GTP+lndiumnanoparticles will improve the delivery of a known chemotherapy drug and enhance the potential for expanded use of this drug in lung and other cancers. Furthermore 111Indium will allow in vivo tracking and imaging of NP without affecting the NP characteristics or biodistribution. This diagnostic capability will enable individualized treatment based on biodistribution, leading to a true personalized medicine product.

* information listed above is at the time of submission.

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