SBIR TOPIC 294 PHASE I - DEVELOPMENT OF GLYCOSYLATION-SPECIFIC RESEARCH REAGENTS (ANTIBODIES AND APTAMERS)

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N43CO110074
Agency Tracking Number: N43CO110074
Amount: $149,951.00
Phase: Phase I
Program: SBIR
Awards Year: 2011
Solicitation Year: 2011
Solicitation Topic Code: NCI
Solicitation Number: N/A
Small Business Information
GLYCOSCIENTIFIC, L.L.C.
220 RIVERBEND RD, ATHENS, GA, 30602-1511
DUNS: 829734347
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 MARIA HINES
 (706) 424-9113
 MH31415927@GMAIL.COM
Business Contact
 MARIA HINES
Phone: (706) 424-9113
Email: MH31415927@GMAIL.COM
Research Institution
 Stub
Abstract
This statement of work concerns a contract for the proposed effort Production of Site?Specific O?GlcNAc Antibodies in response to Small Business Innovation Research (SBIR) Program PHS2011?1. The project seeks to produce monoclonal antibodies (MAbs) to three selected cancer?related protein targets, and more specifically, MAbs that will that will permit detection of the presence of the specific glycosylation within these protein target sites by the O?GlcNAc moiety. For eachof the three (3) selected proteins, a synthetic tripartite immunogen will be synthesized, animals will be immunized to conjugates of this synthetic antigen, and a large number of hybridoma cultures will be produced to be screened for specific interactions. An increasingly stringent regime of immunoassays will be employed to define the specificity and reactivity of the MAbs towards producing reagents that will permit detection of the modification of the particular protein sites by O?GlcNAc. Theprovision of specific reagents that allow detection of the O?GlcNAc modification of the specific sites in these specific proteins will define the utility of the tripartite immunogen approach, as well as supply reagents that will aid in elucidating the role of O?GlcNAc modification in cellular control circuits, including that those that may involve these specific proteins in oncogenesis.

* information listed above is at the time of submission.

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