SBIR TOPIC 294 PHASE 1 - DEVELOPMENT OF GLYCOSYLATION - SPECIFIC RESEARCH

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$148,569.00
Award Year:
2011
Program:
SBIR
Phase:
Phase I
Contract:
N43CO110078
Award Id:
n/a
Agency Tracking Number:
N43CO110078
Solicitation Year:
2011
Solicitation Topic Code:
NCI
Solicitation Number:
n/a
Small Business Information
815 WENNEKER DR, SAINT LOUIS, MO, 63124-2041
Hubzone Owned:
N
Minority Owned:
Y
Woman Owned:
N
Duns:
100512883
Principal Investigator:
LING TAN
(314) 997-5918
TIANL@MEDIOMICS.COM
Business Contact:
LING TAN
(314) 997-5918
TIANL@MEDIOMICS.COM
Research Institution:
Stub




Abstract
Glycosylation changes are a universal feature of malignant transformation and tumor progression. Changes in expression levels of certain glycoproteins and altered glycosylation patterns have been detected in most of the major human cancer types and at different stages of tumor progression. The early detection of glycosylation changes is therefore crucial for cancer diagnosis and treatment. Currently, the methods for glycosylation analysis require expensive instruments and are time consuming. Thus, thereis a need to develop new reagents and simpler methods to study carbohydrate modifications of proteins in cancer biology. Our long term goal is to develop new research reagents for basic cancer researchers in the form of antibodies against N- or O-linked carbohydrate antigens in proteins. In the Phase I proposal, we propose to generate over 32 chicken polyclonal (Task 1) and 2-3 monoclonal IgY (Task 2) against specific Oglycosylation sites. In addition, we will use our proprietary PINCER platform technology to develop 5 costeffective, simple and fast assays (Task 3) to detect protein glycosylation using existing commercially available antibodies. We expect that these PINCER reagents can be used to not only develop homogeneous assays for detecting protein glycosylation, but can also be used as unique imaging reagents.

* information listed above is at the time of submission.

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