TAS::75 0849::TAS TOPIC 255 DEVELOPMENT OF A TARGETED THERAPY FOR ACUTE MYELOID

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$199,833.00
Award Year:
2011
Program:
SBIR
Phase:
Phase I
Contract:
N43CO110093
Award Id:
n/a
Agency Tracking Number:
N43CO110093
Solicitation Year:
2011
Solicitation Topic Code:
NCI
Solicitation Number:
n/a
Small Business Information
11000 CEDAR AVE, CLEVELAND, OH, 44106-3069
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
827446381
Principal Investigator:
MUKESHAGARWAL
(216) 789-6000
MUKESHAGARWAL@CLEVELANDLEUKTHER.COM
Business Contact:
MUKESHAGARWAL
(216) 789-6000
MUKESHAGARWAL@CLEVELANDLEUKTHER.COM
Research Institute:
Stub




Abstract
Acute myeloid leukemia (AML) is one of the most common forms of leukemia in adults and despite advances in treatment the 5 year survival is less than 20-50% in adults and significantly lower in the elderly. The remarkable success in treating one relatively uncommon subset of AML, acute promyelocytic leukemia, with all trans-retinoic acid (ATRA) illustrates the great promise for agents with greater efficacy and less toxicity. Utilizing A TRA, the presumed cure of 75-85% of patients is possible. ATRA's remarkable success stems from the fact that AML is a disease characterized by the arrest of differentiation of immature myeloid cells. A TRA overcomes this block in differentiation by forcing leukemic cells to mature. Unfortunately A TRA does not work clinically for 90-95% of AML patients. We have identified a therapeutic target and an optimized lead compound against this target that leads to differentiation induction in AML patients that are not normally responsive to ATRA. In this application, we willtest the clinical utility of this novel agent for AML using mouse model systems. Provide key

* information listed above is at the time of submission.

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