TAS::75 0849::TAS SBIR TOPIC 304 PHASE I DEVELOPMENT OF BLOOD-BASED METHODS FOR THE DETECTION OF CANCER RECURRENCE IN POST-THERAPY BREAST CANCER PATIENTS

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$298,601.00
Award Year:
2011
Program:
SBIR
Phase:
Phase I
Contract:
N43CO110124
Award Id:
n/a
Agency Tracking Number:
N43CO110124
Solicitation Year:
2011
Solicitation Topic Code:
NCI
Solicitation Number:
n/a
Small Business Information
815 WENNEKER DR, SAINT LOUIS, MO, 63124-2041
Hubzone Owned:
N
Minority Owned:
Y
Woman Owned:
N
Duns:
100512883
Principal Investigator:
LING TIAN
(314) 997-5918
TIANL@MEDIOMICS.COM
Business Contact:
LING TIAN
(314) 997-5918
TIANL@MEDIOMICS.COM
Research Institution:
Stub




Abstract
According to the American Cancer Society, 192,370 women in the United States will be diagnosed with invasive breast cancer in 2010, leading to 40,170 deaths. Most women with breast cancer undergo surgery to remove the cancerous tissue and then receive additional treatment. Adjuvant therapy does not completely remove the risk of late cancer recurrence, even for women with low grade/low stage tumors. Thus, clinicians and patients still need to remain aware of this problem and this problem remains a high priority in our fight against breast cancer. In the past decades, identification and validation of ER, PR and HER2 as molecular markers and therapeutic targets for breast cancer has improved the patient survival. However, other breast cancer biomarkers currently identified lack either disease-related specificity or validated clinical values. Therefore, effective new breast cancer-specific molecular markers for prevention, early detection, and/or targeted treatment of the recurrent diseases are needed. Biomarkerspresent in blood, hold the best promise for disease screening. The goal of this project is to develop simple, quick and cost-effective homogeneous assays to evaluate whether AKR1B10 can be used as a breast cancer recurrence indicator by testing the serumsamples from both cancer-recurrence positive and negative patients.

* information listed above is at the time of submission.

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