SBIR PHASE 1 TOPIC 43

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$149,440.00
Award Year:
2011
Program:
SBIR
Phase:
Phase I
Contract:
N43HB110034
Award Id:
n/a
Agency Tracking Number:
N43HB110034
Solicitation Year:
2011
Solicitation Topic Code:
NHLBI
Solicitation Number:
n/a
Small Business Information
3 E GILL ST, WOBURN, MA, 01801-1720
Hubzone Owned:
N
Minority Owned:
Y
Woman Owned:
N
Duns:
194643722
Principal Investigator:
TREVOR CASTOR
(781) 932-6933
TCASTOR@APHIOS.COM
Business Contact:
TREVOR CASTOR
(781) 932-6933
TCASTOR@APHIOS.COM
Research Institution:
Stub




Abstract
The contractor will identify methodologies for broad spectrum inactivation of pathogens in red blood cell concentrates(RBCC). RBCCs are the main components of blood used in transfusion medicine, yet currently there are no FDAapproved methods for broad spectrum pathogen inactivation for RBCCs; instead, the risk of transfusion associatedpathogen transmission is reduced by screening the transfused blood for specific pathogens. Solvent-detergentmethod, currently approved by FDA for plasma, is active against only enveloped viruses and cannot be used forRBCCs since the RBCCs have a functional plasma membrane. The use of photodynamic compounds such aspsoralens and methylene blue in conjunction with UV light is approved for plasma and platelets in several Europeancountries but the lack of transparency of RBCCs to UV light can pose special challenges to successful and consistentpathogen inactivation in that system.

* information listed above is at the time of submission.

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