High-capacity and Cost-effective Manufacture of Chloroperoxidase

Award Information
Agency:
Department of Defense
Branch
Army
Amount:
$99,889.00
Award Year:
2011
Program:
STTR
Phase:
Phase I
Contract:
W911NF-11-C-0237
Agency Tracking Number:
A11A-014-0054
Solicitation Year:
2011
Solicitation Topic Code:
A11a-T014
Solicitation Number:
2011.A
Small Business Information
Infoscitex Corporation
303 Bear Hill Road, Waltham, MA, -
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
004627316
Principal Investigator:
Vladimir Gilman
Principal Scientist
(781) 890-1338
vgilman@infoscitex.com
Business Contact:
Andrea Hicks
Senior Contract Administrator
(937) 429-9008
ahicks@infoscitex.com
Research Institution:
University of Massachusetts
Linda Concino
One University Ave
Lowell, MA, 01854-
(978) 934-4723
Nonprofit college or university
Abstract
The low cost chloroperoxidase can be potentially applicable to the inactivation of chemical agents due to its exceptional stability, broad substrate profile, and high catalytic efficiency. However, the high cost of producing large amounts of CPO is a major obstacle precluding the formulation and field deployment of this enzyme for chemical agent decontamination. Infoscitex Corporation (IST) and University of Massachusetts at Lowell (UML) propose a technology for high yield commercial production of CPO by an improved strain of filamentous fungus Caldariomyces fumago. The high yields of the enzyme production by C. fumago will be achieved via an advanced method of strain improvement by its directed evolution for target resistance established at Infoscitex. The high activity and stability of the resultant product will be assured by use of the most advanced technology for CPO isolation and purification. The new CPO producing strain will be coupled with state of the art protein production and purification capacity to achieve the required kilogram-scale manufacturing capabilities.

* information listed above is at the time of submission.

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