High-capacity and Cost-effective Manufacture of Chloroperoxidase

Award Information
Agency: Department of Defense
Branch: Army
Contract: W911NF-11-C-0237
Agency Tracking Number: A11A-014-0054
Amount: $99,889.00
Phase: Phase I
Program: STTR
Awards Year: 2011
Solicitation Year: 2011
Solicitation Topic Code: A11a-T014
Solicitation Number: 2011.A
Small Business Information
Infoscitex Corporation
303 Bear Hill Road, Waltham, MA, -
DUNS: 004627316
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Vladimir Gilman
 Principal Scientist
 (781) 890-1338
 vgilman@infoscitex.com
Business Contact
 Andrea Hicks
Title: Senior Contract Administrator
Phone: (937) 429-9008
Email: ahicks@infoscitex.com
Research Institution
 University of Massachusetts
 Linda Concino
 One University Ave
Lowell, MA, 01854-
 (978) 934-4723
 Nonprofit college or university
Abstract
The low cost chloroperoxidase can be potentially applicable to the inactivation of chemical agents due to its exceptional stability, broad substrate profile, and high catalytic efficiency. However, the high cost of producing large amounts of CPO is a major obstacle precluding the formulation and field deployment of this enzyme for chemical agent decontamination. Infoscitex Corporation (IST) and University of Massachusetts at Lowell (UML) propose a technology for high yield commercial production of CPO by an improved strain of filamentous fungus Caldariomyces fumago. The high yields of the enzyme production by C. fumago will be achieved via an advanced method of strain improvement by its directed evolution for target resistance established at Infoscitex. The high activity and stability of the resultant product will be assured by use of the most advanced technology for CPO isolation and purification. The new CPO producing strain will be coupled with state of the art protein production and purification capacity to achieve the required kilogram-scale manufacturing capabilities.

* information listed above is at the time of submission.

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