Cell Culture Approaches to Generating Brown Adipose Tissue for Autologous Transplantation

Award Information
Agency: Department of Defense
Branch: Army
Contract: W81XWH-11-C-0517
Agency Tracking Number: A11A-034-0222
Amount: $98,942.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: A11a-T034
Solicitation Number: 2011.A
Timeline
Solicitation Year: 2011
Award Year: 2011
Award Start Date (Proposal Award Date): 2011-10-03
Award End Date (Contract End Date): N/A
Small Business Information
770 Boylston Street #26G, Boston, MA, -
DUNS: 831412205
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Olivier Boss
 Chief Scientific Officer
 (617) 959-2322
 oboss@energesispharma.com
Business Contact
 Brian Freeman
Title: Chief Operating Officer
Phone: (617) 947-9773
Email: bfreeman@energesispharma.com
Research Institution
 Boston University
 Stephen R Farmer
 Silvio Conte Building, K602
72 E. Concord Street
Boston, MA, 02118-
 (617) 638-4186
 Nonprofit college or university
Abstract
Obesity and its associated metabolic complications including diabetes are becoming increasingly prevalent in the general population as well as in military personnel. Brown adipose tissue (BAT) is a major site of energy expenditure through thermogenesis, which is mediated by the mitochondrial uncoupling protein-1 (UCP1). Studies in animals over the last 30 years as well as recent data in humans strongly suggest that overweight and obese individuals have a low amount of BAT, and that increasing BAT by about 50 grams in obese patients would induce strong weight loss and improve metabolic status (including glucose metabolism, lipid profiles, and cardiovascular risk). This proposal is a feasibility study to define a prototype source and culture system for the generation of human BAT for autologous transplantation therapy. We have recently identified a brown adipocyte progenitor cell population in human muscle, and propose to isolate and characterize the best brown adipocyte progenitor sub-population from human muscle biopsies, expand these cells, and establish the optimal conditions for in vitro differentiation that can generate approximately 50 grams of BAT cells for transplantation.

* Information listed above is at the time of submission. *

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