Modified Nanoparticles for Lipophilic Toxin Sequestration

Award Information
Agency:
Department of Defense
Branch
Air Force
Amount:
$100,000.00
Award Year:
2011
Program:
STTR
Phase:
Phase I
Contract:
FA9550-11-C-0092
Award Id:
n/a
Agency Tracking Number:
F10B-T24-0250
Solicitation Year:
2010
Solicitation Topic Code:
AF10-BT24
Solicitation Number:
2010.B
Small Business Information
1801 Maple Avenue, Suite 4301, Evanston, IL, -
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
831421958
Principal Investigator:
Weston Daniel
Research Scientist
(847) 467-2874
wdaniel@aurasense.com
Business Contact:
Percy Crocker
VP Commercial Development
(847) 467-2874
pcrocker@aurasense.com
Research Institution:
Northwestern University
C. S Thaxton
300 E Superior Street, 16-703
Dept of Urology, Tarry Bldg
Chicago, IL, 60611-
(312) 908-8145
Nonprofit college or university
Abstract
ABSTRACT: Mycotoxins are a class of weaponizable toxic secondary metabolites of molds and fungi. No treatments exist for exposure to these lipophilic poisons. AuraSense proposes to use lipid and protein modified gold nanoparticles to develop constructs for the sequestration of toxic lipophilic molecules. Nanoparticles are ideal materials for development of such a system, as they are able to be finely tuned in terms of their size, molecular composition, surface charge, and interfacial properties. In addition, we have demonstrated in preliminary work that they are nontoxic, and have a proven ability to avidly bind lipophilic molecules. Due to the difficulty of working with mycotoxins, cholesterol will be used as a model system to demonstrate sequestration from cell membranes. BENEFIT: AuraSense"s nanoparticle constructs have great potential as effective agents for transporting lipophilic toxins, such as mycotoxins, safely out of the body. AuraSense nanoparticle technology has been developed in numerous proof-of-concept applications and has been the subject of consistent commercial interest to date. This platform stands to significantly advance defense alternatives in combating lipophilic toxins. While broadly applicable in a number of therapeutic areas, AuraSense"s nanoparticle platforms are highly relevant to the Biodefense market.

* information listed above is at the time of submission.

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