Bioengineering Saccharomyces cerevisiae for the Selective Production of beta-Pinene

Award Information
Agency: Department of Defense
Branch: Navy
Contract: N68335-11-C-0169
Agency Tracking Number: N10B-046-0008
Amount: $69,961.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: N10B-T046
Solicitation Number: 2010.B
Timeline
Solicitation Year: 2010
Award Year: 2011
Award Start Date (Proposal Award Date): 2011-01-10
Award End Date (Contract End Date): N/A
Small Business Information
9 Tabor Hill Rd, Lincoln, MA, 01773-
DUNS: 084592042
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 D. Easson
 Director, BioProcess Divi
 (508) 344-9719
 deasson@impact-td.com
Business Contact
 William Cox
Title: VP Business Development
Phone: (508) 951-2436
Email: bcox@impact-td.com
Research Institution
 Univ of Massachusetts Lowell
 Carl Lawton
 1 University Avenue
Lowell, MA, 01854-2827
 (978) 934-3158
 Nonprofit college or university
Abstract
This technology development program addresses the market and strategic need for renewable high density fuels for missile propulsion or as additives to increase performance of jet propulsion fuels. beta-Pinene, a natural plant derived organic compound, is the proposed high density fuel precursor. In the Phase 1 project, we will demonstrate the feasibility of this approach by: 1) engineering a strain of S. cerevisiae to contain the beta-pinene synthase gene from Artemisia annua. When induced, the engineered strain will divert most of its central metabolism to the production of beta-pinene; 2) demonstrating the ability of the engineered strain to convert hydrolyzed waste cardboard into beta-pinene; 3) developing a solvent extraction system to aid in the recovery of produced beta-pinene; and 4) integrating the beta-pinene production and separation steps in order to demonstrate continuous or semi-continuous operation. In addition we will characterize the overall efficiency of the process by performing material and energy balances. Lastly, we will provide a sample of beta-pinene produced via this bioconversion process.

* Information listed above is at the time of submission. *

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