Design Automation Software for DNA-Based Nano-Sensor Architectures

Award Information
Agency:
Department of Defense
Branch
Office of the Secretary of Defense
Amount:
$100,000.00
Award Year:
2011
Program:
STTR
Phase:
Phase I
Contract:
W911NF-11-C-0082
Award Id:
n/a
Agency Tracking Number:
O10B-003-2001
Solicitation Year:
2010
Solicitation Topic Code:
OSD10-T003
Solicitation Number:
2010.B
Small Business Information
6525 Belcrest Rd, Suite 521, Hyattsville, MD, 20782-2003
Hubzone Owned:
Y
Minority Owned:
N
Woman Owned:
N
Duns:
788153166
Principal Investigator:
Raymond Peterson
Chief Science Officer
(301) 683-2118
peterson@celadonlabs.com
Business Contact:
Lawrence Kessner
Chief Executive Officer
(301) 683-2117
lkessner@celadonlabs.com
Research Institution:
University of Rochester
Tammie Martin
518 Hylan Building
P.O. Box 270140
Rochester, NY, 14627-0140
(585) 275-4031
Nonprofit college or university
Abstract
A continuing and growing threat to U.S. military personnel and civilians is exposure to toxic chemicals and pathogens. Useful detection systems exist, but it remains imperative to investigate next-generation technologies that have the potential to improve by an order of magnitude the cost, sensitivity and size of sensor devices. A promising technology that may achieve these goals is DNA-based nano-sensors. In order for DNA-based nano-sensors to become commercially viable, the technology needs automated assay design software. Towards this end, Celadon will partner with Dr. David H. Mathews, one of the few internationally recognized experts in the computation of nucleic acid structures. During Phase I, the Celadon/Mathews team will compute databases of optimal helices and loops; develop a heuristic algorithm so as to obviate the need to evaluate an entire, computationally intractable, structure; develop a new algorithm for design of pseudo-knots; develop draft versions of Product Requirements, Software Development and Validation Project Plan, Design Specifications, and Technical Specifications; and demonstrate proof-of-concept design software.

* information listed above is at the time of submission.

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