Design Automation Software for DNA-Based Nano-Sensor Architectures

Award Information
Agency: Department of Defense
Branch: Army
Contract: W911NF-11-C-0082
Agency Tracking Number: O10B-003-2001
Amount: $100,000.00
Phase: Phase I
Program: STTR
Awards Year: 2011
Solicitation Year: 2010
Solicitation Topic Code: OSD10-T003
Solicitation Number: 2010.B
Small Business Information
6525 Belcrest Rd, Suite 521, Hyattsville, MD, 20782-2003
DUNS: 788153166
HUBZone Owned: Y
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Raymond Peterson
 Chief Science Officer
 (301) 683-2118
Business Contact
 Lawrence Kessner
Title: Chief Executive Officer
Phone: (301) 683-2117
Research Institution
 University of Rochester
 Tammie Martin
 518 Hylan Building
P.O. Box 270140
Rochester, NY, 14627-0140
 (585) 275-4031
 Nonprofit college or university
A continuing and growing threat to U.S. military personnel and civilians is exposure to toxic chemicals and pathogens. Useful detection systems exist, but it remains imperative to investigate next-generation technologies that have the potential to improve by an order of magnitude the cost, sensitivity and size of sensor devices. A promising technology that may achieve these goals is DNA-based nano-sensors. In order for DNA-based nano-sensors to become commercially viable, the technology needs automated assay design software. Towards this end, Celadon will partner with Dr. David H. Mathews, one of the few internationally recognized experts in the computation of nucleic acid structures. During Phase I, the Celadon/Mathews team will compute databases of optimal helices and loops; develop a heuristic algorithm so as to obviate the need to evaluate an entire, computationally intractable, structure; develop a new algorithm for design of pseudo-knots; develop draft versions of Product Requirements, Software Development and Validation Project Plan, Design Specifications, and Technical Specifications; and demonstrate proof-of-concept design software.

* Information listed above is at the time of submission. *

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