Design Software for DNA-Based Sensing Nano-Architectures

Award Information
Agency:
Department of Defense
Branch
Office of the Secretary of Defense
Amount:
$100,000.00
Award Year:
2011
Program:
STTR
Phase:
Phase I
Contract:
W911NF-11-C-0076
Award Id:
n/a
Agency Tracking Number:
O10B-003-2002
Solicitation Year:
2010
Solicitation Topic Code:
OSD10-T003
Solicitation Number:
2010.B
Small Business Information
11260 Roger Bacon Drive, Suite 406, Reston, VA, -
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
828881305
Principal Investigator:
StevenArmentrout
President
(703) 689-9689
steve@parabon.com
Business Contact:
PaulaGawthorp-Armentrout
Corporate Officer
(703) 689-9689
parmentrout@parabon.com
Research Institute:
Marshall University Research Corp
Janice Morgan
401 11th Street
Suite 1400
Huntington, WV, 25701-2225
(304) 696-2468

Abstract
Beginning from an advanced stage of development, this Phase I SBIR project will produce design automation software for creating DNA nanostructures for a wide variety of applications, remedying a deficit that has stymied advancement in this promising field. Building atop an established grid computing platform, the software will combine a robust, easy-to-use, CAD (computer-aided design) interface, which allows for the specification of complex DNA-based nano-sensor architectures, with a grid-powered sequence optimization engine that computes the sequence-sets required for reliable self-assembly of specified designs. The research plan calls for the integration of a nearest neighbor thermodynamics model with an opportunistic evolutionary search algorithm to effect sequence optimization across a large-scale computational grid. These new capabilities will reduce defects and increase the manufacturing yield of designed nanostructures, and provide designers with novel control over the order of DNA self-assembly, which in turn will lead to products with enhanced functionality. To test the resultant software, a prototype nano-scale molecular capture system will be designed and its formation experimentally validated in Phase I. A capture and reporter bio-sensor system will be developed and demonstrated in Phase II.

* information listed above is at the time of submission.

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