Design Automation Software for DNA-Based Nano-Sensor Architectures

Award Information
Agency: Department of Defense
Branch: Army
Contract: W911NF-11-C-0086
Agency Tracking Number: O10B-003-2004
Amount: $100,000.00
Phase: Phase I
Program: STTR
Awards Year: 2011
Solicitation Year: 2010
Solicitation Topic Code: OSD10-T003
Solicitation Number: 2010.B
Small Business Information
Firebird Biomolecular Sciences, LLC
13709 Progress Boulevard Box 17, Alachua, FL, -
DUNS: 192849011
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Steven Benner
 Manager
 (352) 271-7005
 sbenner@firebirdbio.com
Business Contact
 Romaine Hughes
Title: Administrator
Phone: (352) 271-7005
Email: rhughes@firebirdbio.com
Research Institution
 University of Rochester
 Tammie Martin
 518 Hylan Building
P.O. Box 270140
Rochester, NY, 14627-0140
 (585) 275-4031
 Nonprofit college or university
Abstract
Because of chemical behaviors of real DNA molecules, the nanotechnology envisioned by the Defense Department in this Solicitation will be possible only if design automation software creates nanostructures that exploit artificially expanded genetic information systems (AEGIS). AEGIS DNA molecules have more than the four nucleotides (GACT) found in natural DNA. Our software will accommodate nanoarchitectures built from these four, plus eight additional orthogonally pairing AEGIS nucleotides. By evading the computational challenges associated with natural DNA nanostructures, AEGIS will allow delivery at the end of Phase I, ahead of schedule, software that helps nanotechnologists design nanostructures that incorporate binding and catalytic DNA molecules, sensing functionality, and optical signaling elements. Additional benefits of AEGIS DNA nanostructures are their enhanced stability and potential to support continuous environmental monitoring. Also ahead of schedule, our Phase I work will deliver a physical example of a nanostructure containing these functional elements. This will allow Phase II to focus on higher level nanostructure performance, including dynamic architectures, interfaces to electrical output, and amorphous computing. This project overlaps Firebird's business, which supports human diagnostics based on reagent innovations like AEGIS. Adding nanotechnology to its existing business makes commercial sense, and will help"dual uses"emerge from this project.

* information listed above is at the time of submission.

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