Rapid, noninvasive diagnosis and monitoring of shock

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$162,065.00
Award Year:
2010
Program:
STTR
Phase:
Phase I
Contract:
1R41HL103095-01
Agency Tracking Number:
R41HL103095
Solicitation Year:
2010
Solicitation Topic Code:
NHLBI
Solicitation Number:
PA09-081
Small Business Information
NONINVASIX, INC.
1700 THE STRAND, STE 1.200, GALVESTON, TX, 77555-2240
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
801196960
Principal Investigator:
DONALD PROUGH
(409) 772-2956
dsprough@utmb.edu
Business Contact:
DONALD PROUGH
(409) 772-1221
dsprough@msn.com
Research Institution:
University Of Texas Medical Br Galveston

301 University Blvd
GALVESTON, TX, 77555-
() -
Nonprofit college or university
Abstract
DESCRIPTION (provided by applicant): Assessment and management of circulatory shock in critically ill patients requires rapid measurement of two critical variables: mixed venous oxyhemoglobin saturation (venous SO2) and total blood hemoglobin concentration[Hgb] to identify insufficient oxygen delivery and anemia and to determine the need for therapy with fluids, inotropic or vasodilator drugs or blood transfusion. Current invasive techniques for measurement of venous SO2 and [Hgb] require central venous orpulmonary arterial catheterization and blood sampling. In emergency department patients with septic shock, management based on maintaining venous SO2 at e 70%, as measured invasively in the superior vena cava, reduced mortality from 46.5% to 30.5%. At present, no available noninvasive technique measures venous SO2 and [Hgb] to guide treatment. Our research team has pioneered optoacoustic imaging techniques for accurate, non-invasive, real-time measurement of SO2 and [Hgb]. We designed, built, and performedin vitro and in vivo testing of a novel, compact, high-resolution optoacoustic imaging system that measures SO2 and [Hgb] directly from blood vessels. The optoacoustic imaging is based on generation of ultrasonic (optoacoustic) waves by near infra-red laser light pulses and detection of optoacoustic waves by a sensitive wide-band acoustic transducer. Optoacoustic waves are linearly dependent on SO2 and [Hgb]. Our in vitro and in vivo tests of the system with optoacoustic probes demonstrated that the systemis capable of measuring oxygenation and [Hgb] measurement with high accuracy approaching that of the CO-Oximeter, the conventional gold standard method for measuring oxygen saturation in blood. In this application, our multidisciplinary team of bioengineers and intensivists proposes to develop and test novel, highly-portable clinical, prototype with unique capabilities for rapid, noninvasive assessment and management of circulatory shock in surgical and critically ill patients. PUBLIC HEALTH RELEVANCE: The proposed project will have a substantial impact on care of patients undergoing surgery, critically ill patients, and patients in shock. The proposed optoacoustic system will replace invasive, intermittent diagnostic testing of central venous bloodoxygenation hemoglobin with noninvasive, rapid, and continuous monitoring.

* information listed above is at the time of submission.

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