Hip-Joint Resurfacing with Functional Human Cartilage

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$1,139,179.00
Award Year:
2010
Program:
STTR
Phase:
Phase II
Contract:
2R42AR055414-02
Award Id:
n/a
Agency Tracking Number:
R42AR055414
Solicitation Year:
2010
Solicitation Topic Code:
NIAMS
Solicitation Number:
PA09-081
Small Business Information
2608 ERWIN ROAD, DURHAM, NC, -
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
783502466
Principal Investigator:
LISA FREED
(617) 452-2603
LFreed@draper.com
Business Contact:
GEOFFREY ERICKSON
(919) 684-2521
cytex.therapeutics@gmail.com
Research Institution:
Charles Stark Draper Laboratory

555 Technology Square
CAMBRIDGE, MA, 02139-
() -
Domestic nonprofit research organization
Abstract
DESCRIPTION (provided by applicant): Degenerative joint disease accounts for substantial human suffering at tremendous social and economic cost. While prosthetic joint replacement is a well-established procedure, a finite life span makes this treatment unacceptable for younger or active individuals who often require progressively complicated revision surgeries. The goal of this Phase II STTR is to develop an osteochondral implant suitable for complete resurfacing of the osteoarthritic femoral head of the hip joint and proven ability to integrate with bone. The two novelties of this work are: (i) accelerated generation of an osteochondral implant within a brief period of in vitro culture and (ii) resurfacing of an entire joint instead of a focal defect. We will create a hemispherical layer of cartilage that replicates the load-bearing properties of the native tissue by combining adult human stem cells with a three- dimensionally woven scaffold in a new bioreactor. In vitro growth of the osteochondral implant will be quantified by histomolecular and biomechanical testing, and functional integration with vital bone will be assessed using a subcutaneous pouch model in an immunodeficient rodent. The combination of these emergent regenerative medical technologies isexpected to provide a novel means of developing functional, complex tissue engineered constructs that can resurface large segments of joints that have been affected by degenerative diseases such as osteoarthritis. PUBLIC HEALTH RELEVANCE: This project represents a Phase II STTR project to develop a novel tissue engineering approach to create osteochondral implants for joint resurfacing as a treatment for hip osteoarthritis. The technologic basis involves a combination of adult human mesenchymal stemcells grown on an anatomically shaped, three-dimensionally woven scaffold, which is cultured in a novel bioreactor system that can accelerate the generation of mechanically functional cartilage. The ultimate goal of this study is to develop a tissue engineering approach that can be used to resurface large segments of joints that have been affected by degenerative diseases such as osteoarthritis.

* information listed above is at the time of submission.

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