Kidney Multiphoton Analysis of Therapeutic Agents

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$836,167.00
Award Year:
2010
Program:
STTR
Phase:
Phase II
Contract:
2R42DK076478-02A1
Award Id:
n/a
Agency Tracking Number:
R42DK076478
Solicitation Year:
2010
Solicitation Topic Code:
NIDDK
Solicitation Number:
PA09-081
Small Business Information
1213 ALDERLEY RD, INDIANAPOLIS, IN, -
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
612993936
Principal Investigator:
KENNETH DUNN
(317) 278-0436
kwdunn@iupui.edu
Business Contact:
SIMON ATKINSON
(317) 278-0435
satkinso@iupui.edu
Research Institute:
Indiana University

601 E KIRKWOOD AVE
BLOOMINGTON, IN, 47405-1223
() -
Nonprofit college or university
Abstract
DESCRIPTION (provided by applicant): The rate of drug development is disappointingly slow, in part because of the failure of preclinical drug studies to elucidate the mechanisms of drug actions. INphoton has demonstrated that intravital microscopy can be used as a powerful tool in preclinical drug studies, providing the mechanistic insights typically associated with studies of cultured cells, but in the physiologically relevant context of the intact animal. Here we propose to develop an integrated set of quantitative intravital microscopy assays of renal toxicity, an undesired side-effect of a large number of candidate drug compounds. These assays will be developed using well-established models of renal toxicity in the context of both acute and chronic renalinjury. This project will result in the development of unique research tools that can be used to complement and extend traditional ADME-tox approaches in ways that will expedite drug development. These tools will significantly extend INphoton's capabilities and market, providing the first step in the wide-scale commercialization of INphoton's intravital microscopy services, which will ultimately include capabilities for analyses of other organ systems and of in vivo tumor biology. PUBLIC HEALTH RELEVANCE: INphoton, LLC will commercialize intravital microscopy of the kidney as a contract research service to be used as an investigational tool for preclinical drug development. The high resolution provided by this approach provides unique mechanistic insights into the cellular processing and physiological effects of candidate drug compounds, thereby expediting drug development.

* information listed above is at the time of submission.

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