A simple ventricular assist device for short term cardiac support

Award Information
Agency:
Department of Health and Human Services
Amount:
$523,429.00
Program:
STTR
Contract:
4R42HL096168-02
Solitcitation Year:
2011
Solicitation Number:
N/A
Branch:
N/A
Award Year:
2011
Phase:
Phase II
Agency Tracking Number:
R42HL096168
Solicitation Topic Code:
NHLBI
Small Business Information
MC3, INC.
3550 W LIBERTY RD, STE 3, ANN ARBOR, MI, -
Hubzone Owned:
N
Woman Owned:
N
Socially and Economically Disadvantaged:
N
Duns:
806687406
Principal Investigator
 JONATHAN HAFT
 (734) 995-9089
 haft@umich.edu
Business Contact
 KATHRYN OSTERHOLXER
Phone: (734) 995-9089
Email: koster@mc3corp.com
Research Institution
 REGENTS OF THE UNIVERSITY OF MICHIGAN
 Nonprofit college or university
Abstract
DESCRIPTION (provided by applicant): Cardiogenic shock can occur after open heart surgery or in association with myocardial infarctions, and carries a high mortality. Initiation of mechanical circulatory support can restore blood flow to vital organs and potentially save lives. In this proposal, we plan to develop a device designed to provide temporary mechanical circulatory support which is superior to currently available products in terms of safety, performance, and cost. The proposed BioVad uses the MC3 Mpump as a platform. The BioVad will provide self regulating, versatile, nonthrombogenic and reliable support to any adult patient with cardiogenic shock. We plan to modify the existing MC3 Mpump for prolonged support in the intensive care unit by reducing its size and weight, allowing vacuum assisted drainage, and evaluating surface coatings to reduce blood clot formation. We will test the prototype devices on a simulated circuit for performance, durability, and biocompatibility. We will then apply the device in short and long term animal models, and demonstrate superiority to predicate devices. The device will be refined, and a plan for commercialization will be established. PUBLIC HEALTH RELEVANCE: We propose to develop a temporary mechanical blood pump for the treatment of sudden heart failure and shock. Our prototype BioVad will be superior to currently utilized devices, and we will demonstrate its desirable features using bench simulations as well as short and long term animal studies.

* information listed above is at the time of submission.

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