TAS::75 0893::TAS RAPID QUANTITATIVE POINT OF CARE TEST FOR NICOTINE METABOLITE RATIO, SILOAM BIOSCIENCES, INC. CINCINNATI, OH

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$997,254.00
Award Year:
2011
Program:
SBIR
Phase:
Phase II
Contract:
N44DA110023
Agency Tracking Number:
N44DA110023
Solicitation Year:
2011
Solicitation Topic Code:
NIDA
Solicitation Number:
n/a
Small Business Information
SILOAM BIOSCIENCES, INC.
413 NORTHLAND BLVD, CINCINNATI, OH, 45219-2333
Hubzone Owned:
N
Socially and Economically Disadvantaged:
Y
Woman Owned:
N
Duns:
142009583
Principal Investigator:
ANIRUDDHA PUNTAMBEKAR
(513) 429-2976
ANIRUDDHA@SILOAMBIO.COM
Business Contact:
ANIRUDDHA PUNTAMBEKAR
(513) 429-2976
ANIRUDDHA@SILOAMBIO.COM
Research Institution:
Stub




Abstract
Recent clinical research has established that this ratio is indicative of the activity of the CYP2A6 enzyme that metabolises nicotine. Nicotine is metabolized to COT and then to 3HC. People with high activity of this enzyme, clear nicotine faster and henceneed more nicotine to maintain the addiction. To-date the 3HC/COT ratio could only be determined by specialized measurement techniques such as Liquid-Chromatography/Mass Spectrometry. Although accurate, these tests are expensive and take 2-5 days to deliver results. Smoking is the leading cause of cancer related deaths, and is attributable cause for almost 400,000 deaths per year in the US> The POCT for nicotine metabolites can help in increasing smoking cessation rates and directly contribute to reduced mortality/healthcare burden.

* information listed above is at the time of submission.

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