TAS::75 0893::TAS RAPID QUANTITATIVE POINT OF CARE TEST FOR NICOTINE METABOLITE RATIO, SILOAM BIOSCIENCES, INC. CINCINNATI, OH

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N44DA110023
Agency Tracking Number: N44DA110023
Amount: $997,254.00
Phase: Phase II
Program: SBIR
Awards Year: 2011
Solicitation Year: 2011
Solicitation Topic Code: NIDA
Solicitation Number: N/A
Small Business Information
413 NORTHLAND BLVD, CINCINNATI, OH, 45219-2333
DUNS: 142009583
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: Y
Principal Investigator
 ANIRUDDHA PUNTAMBEKAR
 (513) 429-2976
 ANIRUDDHA@SILOAMBIO.COM
Business Contact
 ANIRUDDHA PUNTAMBEKAR
Phone: (513) 429-2976
Email: ANIRUDDHA@SILOAMBIO.COM
Research Institution
 Stub
Abstract
Recent clinical research has established that this ratio is indicative of the activity of the CYP2A6 enzyme that metabolises nicotine. Nicotine is metabolized to COT and then to 3HC. People with high activity of this enzyme, clear nicotine faster and henceneed more nicotine to maintain the addiction. To-date the 3HC/COT ratio could only be determined by specialized measurement techniques such as Liquid-Chromatography/Mass Spectrometry. Although accurate, these tests are expensive and take 2-5 days to deliver results. Smoking is the leading cause of cancer related deaths, and is attributable cause for almost 400,000 deaths per year in the US> The POCT for nicotine metabolites can help in increasing smoking cessation rates and directly contribute to reduced mortality/healthcare burden.

* Information listed above is at the time of submission. *

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