Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N44HD090017
Agency Tracking Number: N44HD090017
Amount: $425,949.00
Phase: Phase II
Program: SBIR
Awards Year: 2011
Solicitation Year: 2011
Solicitation Topic Code: NICHD
Solicitation Number: N/A
Small Business Information
654 JEFFERSON AVE, MEMPHIS, TN, 38105-4912
DUNS: 071850080
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: Y
Principal Investigator
 (901) 578-5708
Business Contact
Phone: (901) 578-5708
Research Institution
Alcohol abuse and its related health effects are estimated to have an economic cost in the US that approaches $200 Billion per year. However, current tests for alcohol use/abuse are not reliable except when administered within several hours of intoxication. Moreover, current clinical tests for alcohol-related organ damage only provide reasonable diagnostic and prognostic value after the damage has occurred. This study is designed to examine the effect of alcohol on micro RNAs (miRNAs), a newly discovered class of gene expression regulators that are believed to play important roles in vital cellular functions, development and disease. Genome Explorations Inc. (GenEx) proposes to use a well-validated mouse model system to identify alcohol-induced changes in miRNA expression in blood, liver and cerebellum and assess their ability to act as sensitive and specific indicators of acute alcohol use and alcohol-induced liver damage. Identification of such biomarkers may lead to the development of more sensitive and specific tests that can detect alcohol consumption well after the fact, and the early onset (or pre-onset indicators) of alcohol induced liver damage.

* Information listed above is at the time of submission. *

Agency Micro-sites

SBA logo
Department of Agriculture logo
Department of Commerce logo
Department of Defense logo
Department of Education logo
Department of Energy logo
Department of Health and Human Services logo
Department of Homeland Security logo
Department of Transportation logo
Environmental Protection Agency logo
National Aeronautics and Space Administration logo
National Science Foundation logo
US Flag An Official Website of the United States Government