The Effector Trap: A New Tool for Virulence Factor Discovery

Award Information
Agency: Department of Defense
Branch: Defense Advanced Research Projects Agency
Contract: W31P4Q-11-C-0220
Agency Tracking Number: 11SB1-0045
Amount: $99,945.00
Phase: Phase I
Program: SBIR
Awards Year: 2011
Solicitation Year: 2011
Solicitation Topic Code: SB111-002
Solicitation Number: 2011.1
Small Business Information
130 North Main Street, Suite 600, Butte, MT, -
DUNS: 836287680
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Claire Checroun
 Principal Investigator
 (406) 497-5245
Business Contact
 Lawrence Farrar
Title: President
Phone: (406) 497-5252
Research Institution
The accelerating prevalence of antibiotic-resistant bacterial strains is an increasing public health problem. While the emergence of resistant strains is unavoidable, it is exacerbated by the widespread use, inappropriate prescription and misuse of antibiotics. Development of new antibiotics is slow and costly. One alternative to antibiotics is the development of antimicrobials that target the bacteria virulence factors. Such drugs will exert a milder selection pressure and should reduce the likelihood of development of resistant sub-populations. Resodyn Corporation proposes to develop an"Effector Trap": a new platform and a packaging that will allow a rapid and efficient isolation of virulence factors from multiple bacteria by exposing them artificially to the cues they normally encounter in vivo. The platform setup will allow for direct recovery of concentrated solutions containing the virulence factors, providing targets for the development of virulence factor-based antimicrobial compounds.x

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