Integrated Lab-on-chip Universal Bio-sample Preparation Module

Award Information
Agency: Department of Defense
Branch: Army
Contract: W911NF-11-C-0050
Agency Tracking Number: A102-074-0517
Amount: $69,986.00
Phase: Phase I
Program: SBIR
Awards Year: 2011
Solicitation Year: 2010
Solicitation Topic Code: A10-074
Solicitation Number: 2010.2
Small Business Information
8100 Shaffer Parkway, Suite #130, Littleton, CO, -
DUNS: 148034408
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Xichun Zhou
 Senior Research Scientist
 (303) 792-5615
Business Contact
 Clifton Brown
Title: President&CEO
Phone: (303) 792-5615
Research Institution
We propose to develop a self-contained, integrated, disposable universal sampling platform that enables streamlined workflow in the preparation of viral and bacterial sample and obtaining PCR-ready nucleic acids and immuno-reactive content from a variety of sample matrices such as water, whole blood and plasma (virtually any biological matrix). The platform consist a low cost, disposable, microfluidic-based cassette. The cassette accepts a sample of biological fluid and performs lysis; nucleic acid isolation, concentration, as well as protein isolation and purification. The cassette stores on-board all the required buffers and dry reagents, as well as, provides on-chip pumping and flow control. The performance of the module device will be evaluated and tested by identifying the presence of Bacteria E. Coli in spiked samples. The proposed sample preparation system will allow the non-skilled user to process raw samples in a rapid, simple process, enabling push button automated lysis, concentration and purification of isolation of disease specific RNA and DNA, peptides and proteins.

* Information listed above is at the time of submission. *

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