Multiagent Synthetic DNA Vaccines Delivered by Noninvasive Electroporation

Award Information
Agency:
Department of Defense
Branch
n/a
Amount:
$69,670.00
Award Year:
2011
Program:
SBIR
Phase:
Phase I
Contract:
W81XWH-11-C-0051
Award Id:
n/a
Agency Tracking Number:
A103-155-0133
Solicitation Year:
2010
Solicitation Topic Code:
A10-155
Solicitation Number:
2010.3
Small Business Information
11494 Sorrento Valley Road, Suite A, San Diego, CA, -
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
879167674
Principal Investigator:
KateBroderick
Associate Director, R&D
(858) 410-3161
kbroderick@inovio.com
Business Contact:
NiranjanSardesai
Sr VP, Research&Development
(267) 440-4232
nsardesai@inovio.com
Research Institute:
Stub




Abstract
Inovio Pharmaceuticals current minimally invasive dermal electroporation prototype device, which uses low voltage parameters to achieve both high and consistent levels of immunogenicity, offers an attractive option as an efficient and tolerable method for delivering DNA vaccinations in a clinical setting. For this submission, we propose to develop a multi-headed electroporation platform based on optimized version of the current device. This new device would remain an effective means to deliver DNA vaccines while maintaining the tolerability of a surface dermal electroporation method. Additionally, this device could simultaneously delivery two or more DNA vaccines at spatially separate sites, negating any issues with interference and reducing vaccine burden. The production of such a device which could simultaneously deliver multiple plasmid vaccines would offer a significant advance in the field of DNA vaccinations.

* information listed above is at the time of submission.

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