Software Tool for Complex Biomarker Discovery

Award Information
Agency: Department of Defense
Branch: Army
Contract: W81XWH-11-C-0041
Agency Tracking Number: A103-159-0107
Amount: $69,758.00
Phase: Phase I
Program: SBIR
Awards Year: 2011
Solitcitation Year: 2010
Solitcitation Topic Code: A10-159
Solitcitation Number: 2010.3
Small Business Information
TopGear Automation
567 Riverbend, Pearisburg, VA, -
Duns: 829165377
Hubzone Owned: Y
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Brett Malone
 President
 (540) 250-1628
 bmalone@topgearautomation.com
Business Contact
 Brett Malone
Title: President
Phone: (540) 250-1628
Email: bmalone@topgearautomation.com
Research Institution
 Stub
Abstract
A new algorithm is proposed to identify hazards based on high-fidelity correlation between gene expressions and pathway signals. A software implementation based on'energy score'method has been developed to detect multiple gene interactions in the pursuit of specific signal pathways within key cells of interest. This method, Graphical Random Walk (GRW) is robust, highly sensitive, and unlike methods of binary descent, can detect very low continuous exposures. Proof of feasibility and the application of this methodology toward monitoring for toxic threats and exposures will provide the US Army with a significantly improved defense against short term and long term threats.

* information listed above is at the time of submission.

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