Software Tool for Complex Biomarker Discovery

Award Information
Agency:
Department of Defense
Branch
n/a
Amount:
$69,758.00
Award Year:
2011
Program:
SBIR
Phase:
Phase I
Contract:
W81XWH-11-C-0041
Agency Tracking Number:
A103-159-0107
Solicitation Year:
2010
Solicitation Topic Code:
A10-159
Solicitation Number:
2010.3
Small Business Information
TopGear Automation
567 Riverbend, Pearisburg, VA, -
Hubzone Owned:
Y
Minority Owned:
N
Woman Owned:
N
Duns:
829165377
Principal Investigator:
Brett Malone
President
(540) 250-1628
bmalone@topgearautomation.com
Business Contact:
Brett Malone
President
(540) 250-1628
bmalone@topgearautomation.com
Research Institution:
Stub




Abstract
A new algorithm is proposed to identify hazards based on high-fidelity correlation between gene expressions and pathway signals. A software implementation based on'energy score'method has been developed to detect multiple gene interactions in the pursuit of specific signal pathways within key cells of interest. This method, Graphical Random Walk (GRW) is robust, highly sensitive, and unlike methods of binary descent, can detect very low continuous exposures. Proof of feasibility and the application of this methodology toward monitoring for toxic threats and exposures will provide the US Army with a significantly improved defense against short term and long term threats.

* information listed above is at the time of submission.

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