Software Tool for Complex Biomarker Discovery

Award Information
Agency: Department of Defense
Branch: Army
Contract: W81XWH-11-C-0036
Agency Tracking Number: A103-159-0136
Amount: $66,000.00
Phase: Phase I
Program: SBIR
Awards Year: 2011
Solicitation Year: 2010
Solicitation Topic Code: A10-159
Solicitation Number: 2010.3
Small Business Information
IFXworks LLC
21100 Dulles Town Cir, Suite 256, Dulles, VA, -
DUNS: 829238810
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Xianfeng Chen
 Partner, CSO
 (202) 552-8326
 vm@ifxworks.com
Business Contact
 Vladimir Makarov
Title: Partner
Phone: (202) 552-8326
Email: vm@ifxworks.com
Research Institution
 Stub
Abstract
We propose development of a feature discovery algorithm for identification of multivariate (or composition) biomarker signatures from high-dimensional omics data. The proposed algorithm operates on sets of heterogeneous features and returns a selected subset of significant features and a continuous quantitative metric that is indicative of a particular state of the data (i.e. presence or absence of a toxic hazard). There is no requirement that all features analyzed be of the same type; therefore, the algorithm allows for input of a mixture of data types. The types of data suitable for analysis may be gene expression values, gene copy numbers, presence of particular mutations or SNPs, or methylation patterns. Initially this algorithm was formulated for mining for complex biomarkers in oncology, and is extended here for the purpose of continuous monitoring of environmental and chemical hazards.

* information listed above is at the time of submission.

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