Software Tool for Complex Biomarker Discovery

Award Information
Agency: Department of Defense
Branch: Army
Contract: W81XWH-11-C-0038
Agency Tracking Number: A103-159-0389
Amount: $70,000.00
Phase: Phase I
Program: SBIR
Awards Year: 2011
Solicitation Year: 2010
Solicitation Topic Code: A10-159
Solicitation Number: 2010.3
Small Business Information
Celadon Laboratories, Inc.
6525 Belcrest Rd, Hyattsville, MD, -
DUNS: 788153166
HUBZone Owned: Y
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Raymond Peterson
 Chief Science Officer
 (301) 683-2118
Business Contact
 Lawrence Kessner
Title: Chief Executive Officer
Phone: (301) 683-2117
Research Institution
A continuing and growing threat to U.S. military personnel and civilians is exposure to toxic chemicals and pathogens. Because of this, detection of exposure to chemical and biological agents is a priority for biodefense, combat readiness, and public health. One promising approach is to measure response of global gene, small RNA, and/or protein expression to varying levels and time courses of exposure. However, many studies suffer from a lack of reproducibility, and current procedures are often limited to comparing only two outcomes. In Phase I, Celadon, in partnership with David M. Rocke, Ph.D., Director, UC Davis Center for Biomarker Discovery, and Distinguished Professor of Biostatistics, will develop improved procedures and workflows for measuring response of global gene, small RNA, and/or protein expression to varying levels and time courses of toxicant exposure. With a prototype user interface, researchers will be able to select, rank, validate, and verify biomarkers and biomarker signatures. Hundreds to tens of thousands of transcripts or proteins are expected in each data set.

* information listed above is at the time of submission.

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