Time-Released Nitric Oxide for the Treatment of Military Wound Infections

Award Information
Agency: Department of Defense
Branch: Army
Contract: W81XWH-11-C-0029
Agency Tracking Number: A103-160-0228
Amount: $69,821.00
Phase: Phase I
Program: SBIR
Awards Year: 2011
Solicitation Year: 2010
Solicitation Topic Code: A10-160
Solicitation Number: 2010.3
Small Business Information
Novan, Inc.
PO Box 110023, Research Triangle Pa, NC, -
DUNS: 621609556
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Nathan Stasko
 (919) 485-8080
Business Contact
 Cari Green
Title: Business Manager
Phone: (919) 485-8080
Email: cgreen@novanonline.com
Research Institution
Under battlefield conditions, warfighters face a wide range of cutaneous injuries, many of which are susceptible to life- and limb-threatening microbial infections caused by multi-drug resistant bacteria. Nitric oxide is a powerful, broad spectrum antimicrobial agent that is naturally produced by the immune system. Nitric oxide"s ability to attack multiple cellular targets limits the chance for bacteria to develop resistance to it. The use of nitric oxide to treat infections has been hindered by the challenges associated with chemically storing the gas into a solid state and controlling its release. Novan"s nitric oxide-releasing silica technology, Nitricil, overcomes the past issues with nitric oxide-based therapeutics because it effectively stores large quantities of nitric oxide gas and allows the release to be"tuned"for use in acute trauma scenarios or longer term wound care applications. The technical innovation and flexibility of Nitricil clearly separates it from all other nitric oxide storage scaffolds. The goal of this Phase I research is to demonstrate the tunability of the Nitricil platform and the stability of topical gels packaged in portable, single use sachets which may ultimately lead to a series of topical wound care products for the treatment of military infections.

* information listed above is at the time of submission.

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