Controlled Release of Topical Nitric Oxide for Treating Cutaneous Injuries

Award Information
Agency: Department of Defense
Branch: Army
Contract: W81XWH-11-C-0031
Agency Tracking Number: A103-160-0345
Amount: $70,000.00
Phase: Phase I
Program: SBIR
Awards Year: 2011
Solitcitation Year: 2010
Solitcitation Topic Code: A10-160
Solitcitation Number: 2010.3
Small Business Information
Zeomedix, LLC
26 Ashlawn Circle, Malvern, PA, -
Duns: 832603067
Hubzone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 John Aybar
 (610) 517-7818
Business Contact
 John Aybar
Title: CEO
Phone: (610) 517-7818
Research Institution
In this proposal Zeomedix proposes to develop a dressing for acute trauma wounds based on its alginate/zeolite encapsulating nitric oxide (NO) technology. Nitric oxide has been shown to enhance the wound healing process as well as act as a powerful antibacterial agent. However, delivery of nitric oxide to a wound area is extremely challenging because NO is a gas. Zeomedix"s approach is to use zeolites that bind NO molecules when exposed to a stream of gaseous NO. When NO-loaded zeolites come in contact with water (or wound fluid), NO is released into the wound area. The aims of this project are to (1) develop a wound dressing that achieve a rapid initial burst of NO for antimicrobial effect followed by a slow extended release of NO for up to 24 hours to accelerate wound closure; (2) demonstrate the stability of a NO-zeolite based wound dressing over a period of up to 4 months; and (3) to demonstrate the antimicrobial effectiveness of a NO-zeolite based wound dressing.

* information listed above is at the time of submission.

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