Controlled Release of Topical Nitric Oxide for Treating Cutaneous Injuries

Award Information
Agency: Department of Defense
Branch: Army
Contract: W81XWH-11-C-0031
Agency Tracking Number: A103-160-0345
Amount: $70,000.00
Phase: Phase I
Program: SBIR
Awards Year: 2011
Solicitation Year: 2010
Solicitation Topic Code: A10-160
Solicitation Number: 2010.3
Small Business Information
26 Ashlawn Circle, Malvern, PA, -
DUNS: 832603067
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 John Aybar
 CEO
 (610) 517-7818
 aybarc@gmail.com
Business Contact
 John Aybar
Title: CEO
Phone: (610) 517-7818
Email: aybarc@gmail.com
Research Institution
 Stub
Abstract
In this proposal Zeomedix proposes to develop a dressing for acute trauma wounds based on its alginate/zeolite encapsulating nitric oxide (NO) technology. Nitric oxide has been shown to enhance the wound healing process as well as act as a powerful antibacterial agent. However, delivery of nitric oxide to a wound area is extremely challenging because NO is a gas. Zeomedix"s approach is to use zeolites that bind NO molecules when exposed to a stream of gaseous NO. When NO-loaded zeolites come in contact with water (or wound fluid), NO is released into the wound area. The aims of this project are to (1) develop a wound dressing that achieve a rapid initial burst of NO for antimicrobial effect followed by a slow extended release of NO for up to 24 hours to accelerate wound closure; (2) demonstrate the stability of a NO-zeolite based wound dressing over a period of up to 4 months; and (3) to demonstrate the antimicrobial effectiveness of a NO-zeolite based wound dressing.

* Information listed above is at the time of submission. *

Agency Micro-sites

SBA logo
Department of Agriculture logo
Department of Commerce logo
Department of Defense logo
Department of Education logo
Department of Energy logo
Department of Health and Human Services logo
Department of Homeland Security logo
Department of Transportation logo
Environmental Protection Agency logo
National Aeronautics and Space Administration logo
National Science Foundation logo
US Flag An Official Website of the United States Government