Controlled Release of Topical Nitric Oxide for Treating Cutaneous Injuries

Award Information
Agency:
Department of Defense
Branch
n/a
Amount:
$70,000.00
Award Year:
2011
Program:
SBIR
Phase:
Phase I
Contract:
W81XWH-11-C-0031
Agency Tracking Number:
A103-160-0345
Solicitation Year:
2010
Solicitation Topic Code:
A10-160
Solicitation Number:
2010.3
Small Business Information
Zeomedix, LLC
26 Ashlawn Circle, Malvern, PA, -
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
832603067
Principal Investigator:
John Aybar
CEO
(610) 517-7818
aybarc@gmail.com
Business Contact:
John Aybar
CEO
(610) 517-7818
aybarc@gmail.com
Research Institution:
Stub




Abstract
In this proposal Zeomedix proposes to develop a dressing for acute trauma wounds based on its alginate/zeolite encapsulating nitric oxide (NO) technology. Nitric oxide has been shown to enhance the wound healing process as well as act as a powerful antibacterial agent. However, delivery of nitric oxide to a wound area is extremely challenging because NO is a gas. Zeomedix"s approach is to use zeolites that bind NO molecules when exposed to a stream of gaseous NO. When NO-loaded zeolites come in contact with water (or wound fluid), NO is released into the wound area. The aims of this project are to (1) develop a wound dressing that achieve a rapid initial burst of NO for antimicrobial effect followed by a slow extended release of NO for up to 24 hours to accelerate wound closure; (2) demonstrate the stability of a NO-zeolite based wound dressing over a period of up to 4 months; and (3) to demonstrate the antimicrobial effectiveness of a NO-zeolite based wound dressing.

* information listed above is at the time of submission.

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