KINETICALLY CONTROLLABLE, THERAPEUTIC TOPICAL DELIVERY OF NITRIC OXIDE THROUGH NOVEL BIODEGRADABLE"PSEUDO-PROTEIN"BIOMATERIALS

Award Information
Agency: Department of Defense
Branch: Army
Contract: W81XWH-11-C-0032
Agency Tracking Number: A103-160-0457
Amount: $69,900.00
Phase: Phase I
Program: SBIR
Awards Year: 2011
Solicitation Year: 2010
Solicitation Topic Code: A10-160
Solicitation Number: 2010.3
Small Business Information
950 Danby Road, Suite 300, Ithaca, NY, -
DUNS: 824968477
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Aaron Strickland
 VP, Research and Development
 (607) 227-7522
 astrick@ifyber.com
Business Contact
 Eric Eisenhut
Title: President
Phone: (607) 330-2307
Email: ee@ifyber.com
Research Institution
 Stub
Abstract
iFyber LLC, the lead company for this project, will partner with Prof. CC Chu from Cornell University, a recognized expert in the development and study of new drug-eluting biomaterials for wound healing, to develop a platform technology for controlled release of nitric using a newly invented family of novel biodegradable amino acid-based poly(ester amide)s (AA-PEAs). These pseudo-protein biomaterials have been engineered into different physical forms including gels, fibrous membranes, micro/nanospheres. These novel pseudo-protein biomaterials have already been demonstrated in vitro and in vivo to elicit far lower levels of inflammation than existing FDA-approved commercial biomaterials. The current efforts will exploit AA-PEA-based biodegradable biomaterials that are enzymatically biodegradable and have pendant functional groups that can be used to conjugate condensed-phase nitric oxide (NO) moieties. Controlled release of nitric oxide with be fine-tuned using a combination of NO moiety breakdown and enzymatic biodegradation of the NO-containing AA-PEA biomaterials.

* Information listed above is at the time of submission. *

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