KINETICALLY CONTROLLABLE, THERAPEUTIC TOPICAL DELIVERY OF NITRIC OXIDE THROUGH NOVEL BIODEGRADABLE"PSEUDO-PROTEIN"BIOMATERIALS

Award Information
Agency:
Department of Defense
Branch
Army
Amount:
$69,900.00
Award Year:
2011
Program:
SBIR
Phase:
Phase I
Contract:
W81XWH-11-C-0032
Agency Tracking Number:
A103-160-0457
Solicitation Year:
2010
Solicitation Topic Code:
A10-160
Solicitation Number:
2010.3
Small Business Information
IFyber, LLC
950 Danby Road, Suite 300, Ithaca, NY, -
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
824968477
Principal Investigator:
Aaron Strickland
VP, Research and Development
(607) 227-7522
astrick@ifyber.com
Business Contact:
Eric Eisenhut
President
(607) 330-2307
ee@ifyber.com
Research Institution:
Stub




Abstract
iFyber LLC, the lead company for this project, will partner with Prof. CC Chu from Cornell University, a recognized expert in the development and study of new drug-eluting biomaterials for wound healing, to develop a platform technology for controlled release of nitric using a newly invented family of novel biodegradable amino acid-based poly(ester amide)s (AA-PEAs). These pseudo-protein biomaterials have been engineered into different physical forms including gels, fibrous membranes, micro/nanospheres. These novel pseudo-protein biomaterials have already been demonstrated in vitro and in vivo to elicit far lower levels of inflammation than existing FDA-approved commercial biomaterials. The current efforts will exploit AA-PEA-based biodegradable biomaterials that are enzymatically biodegradable and have pendant functional groups that can be used to conjugate condensed-phase nitric oxide (NO) moieties. Controlled release of nitric oxide with be fine-tuned using a combination of NO moiety breakdown and enzymatic biodegradation of the NO-containing AA-PEA biomaterials.

* information listed above is at the time of submission.

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