Multifunctional Antisense Therapeutics Nanocarrier and Inhalation Device

Award Information
Agency:
Department of Defense
Branch
n/a
Amount:
$749,988.00
Award Year:
2011
Program:
SBIR
Phase:
Phase II
Contract:
HDTRA1-11-C-0035
Agency Tracking Number:
C2-0330
Solicitation Year:
2011
Solicitation Topic Code:
CBD10-102
Solicitation Number:
2011.1
Small Business Information
Physical Optics Corporation
Photonic Systems Division, 20600 Gramercy Place, Bldg. 100, Torrance, CA, -
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
Y
Duns:
153865951
Principal Investigator:
Gregory Zeltser
Principal Scientist
(310) 320-3088
psproposals@poc.com
Business Contact:
Gordon Drew
Chief Financial Officer
(310) 320-3088
gedrew@poc.com
Research Institution:
n/a
Abstract
To address the CBD need for improved formulations to enhance the ease of use and bioavailability of antisense therapeutics, Physical Optics Corporation (POC) proposes to advance development of a Multifunctional Antisense Therapeutics Nanocarrier and Inhalation Device (MATEN). This proposed system is based on a new dry powder formulation and a novel design of an inhaler that uses mature components developed in-house. POC"s innovations in the nanocarrier (NC) construct and in the design of the inhaler make it possible to deliver a single dose with the MATEN during one deep and slow inspiration. The MATEN enhances the bioavailability for antisense therapeutics that is necessary for the prophylaxes and early treatment of warfighters against emerging bio-warfare threats. Its formulation is stable at ambient temperature, minimizes the potential for introducing immunogenic materials, reduces the bulk and complexity of dispensing, and directly addresses the requirements of the Transformational Medical Technologies Initiative (TMTI) program. In Phase I, POC demonstrated the feasibility of the MATEN by demonstrating product stability and establishing enhanced bioavailability in an animal model. In Phase II, POC will optimize candidate formulation for maximum bioavailability and conduct initial pharmacokinetic and pharmacodynamic studies in an animal model.

* information listed above is at the time of submission.

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