Blood Brain Barrier Drug Delivery of Therapeutics for Chemical Warfare Agents

Award Information
Agency:
Department of Defense
Branch
Office for Chemical and Biological Defense
Amount:
$749,641.00
Award Year:
2011
Program:
SBIR
Phase:
Phase II
Contract:
W81XWH-10-C-0238
Agency Tracking Number:
C2-0349
Solicitation Year:
2010
Solicitation Topic Code:
CBD10-109
Solicitation Number:
2010.1
Small Business Information
Impel NeuroPharma
867 SW Shoremont Ave, Normandy Park, WA, -
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
827915385
Principal Investigator:
John Hoekman
Chief Scientific Officer
(206) 568-1466
hoekman@impelneuropharma.com
Business Contact:
Michael Hite
Chief Executive Officer
(206) 697-5817
hite@impelneuropharma.com
Research Institution:
Stub




Abstract
Technical Abstract Impel NeuroPharma has developed a novel non-invasive delivery system, the POD device that targets drug to the upper third of the nasal cavity which results in direct and rapid transport of drug to the CNS via the olfactory perineural pathways, effectively bypassing the BBB. In Phase I of this research contract Impel successfully characterized and tested both an aqueous and a dry powder form of 2-PAM for administration via Impel"s POD device, which led to dramatic increases in 2-PAM brain concentrations and lower plasma concentrations compared to IV administration. In Phase 2 of this research contract, Impel will conduct critical studies in order to ready this product for clinical trials and ultimately for use in the battlefield setting as an effective treatment for nerve gas exposure. Impel"s four main objectives are 1) Determine doses of POD administered 2-PAM and MMB-4 with optimal CNS exposure in rats; 2) Demonstrate the CNS protective effects of POD administered 2-PAM and MMB-4 in rats exposed to the nerve agents sarin and soman; 3) Develop optimized POD device for battlefield oxime use; and 4) Determine tolerability and drug distribution of POD administered oxime in non-human primates.

* information listed above is at the time of submission.

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