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Neuromonitoring of Traumatic Brain/blast Injury

Award Information
Agency: Department of Defense
Branch: Defense Health Agency
Contract: W81XWH-10-C-0059
Agency Tracking Number: O2-1033
Amount: $609,534.00
Phase: Phase II
Program: SBIR
Solicitation Topic Code: OSD09-H06
Solicitation Number: 2009.3
Solicitation Year: 2009
Award Year: 2011
Award Start Date (Proposal Award Date): 2011-07-11
Award End Date (Contract End Date): N/A
Small Business Information
P.O. Box 8175
Charlottesville, VA -
United States
DUNS: 942413162
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Martin Baruch, PhD
 Chief Scientist
 (434) 296-7000
Business Contact
 David Gerdt, PhD
Title: President
Phone: (434) 296-7000
Research Institution

The objective of the proposed program is the development of a mobile and non-invasive cerebro-physiological monitor that will permit the tracking of cerebral functions and the identification of developing pathologic brain conditions in wounded soldiers during transport and under medical care in forward areas. Specifically, the purpose of the system will be to continuously track cerebral blood flow and perfusion by monitoring the state of autoregulation as well as by monitoring an EEG signal as a further detection mechanism for declining brain function. As part of the Phase I effort a working prototype system was designed, built, and tested. The approach of correlating REG signals and continuous blood pressure, using the CareTaker physiological monitor, to track cerebral autoregulation was demonstrated on a preliminary basis. Different signal processing approaches were examined and down-selected. The proposed Phase II effort will entail miniaturization of the hardware, FDA-approval process initiation and the validation of the brain monitoring concept in clinical studies, involving the monitoring of neuro-ICU patients as well as autoregulation manipulation in volunteers, as well as animal studies.

* Information listed above is at the time of submission. *

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