Keratin Biomaterials for Cranio-facial Tissue Engineering

Award Information
Agency:
Department of Defense
Branch
Defense Health Program
Amount:
$749,994.00
Award Year:
2011
Program:
SBIR
Phase:
Phase II
Contract:
W81XWH-10-C-0165
Award Id:
n/a
Agency Tracking Number:
O2-1042
Solicitation Year:
2009
Solicitation Topic Code:
OSD09-H10
Solicitation Number:
2009.3
Small Business Information
Richard Dean Research Building, Suite 168, 391 Technology Way, Winston-Salem, NC, -
Hubzone Owned:
Y
Minority Owned:
N
Woman Owned:
N
Duns:
827054219
Principal Investigator:
Luke Burnett
Director Product Developm
(336) 202-1307
luke.burnett@keranetics.com
Business Contact:
Kim Westmoreland
Managing Director
(336) 918-6404
kim.westmoreland@keranetics.com
Research Institute:
Stub




Abstract
The majority of personnel injured in OIF/OEF have suffered blast injuries from IEDs. Blasts often cause cranio-facial trauma that is difficult to repair surgically. The current standard of care involves the placement of fixation devices and off label use of growth factor carriers. These strategies often require multiple surgical interventions creating a significant need for better technologies that can be used in minimally invasive procedures. A family of biomaterials derived from keratin proteins may provide a platform on which new strategies can be built. Keratins have broad biocompatibility and can be formulated as films, fibers, foams, solid tissue constructs and important to this project, hydrogels. One of the problems with many synthetic and naturally derived biomaterials is that they do not promote cell adhesion and migration into scaffolds that have weak cell-matrix interactions. Keratins have intrinsic cell-binding properties that can be exploited to offer new solutions to cranio-facial regeneration. This Phase II proposal seeks to expand on Phase I data by testing an injectable keratin growth factor carrier in both large and small animal models of mandible defects. The results will be used in an application to the FDA to begin clinical trials for injuries of cranio-facial bone structures.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government