Neuromonitoring of Traumatic Brain/blast Injury

Award Information
Agency:
Department of Defense
Branch
Army
Amount:
$749,994.00
Award Year:
2011
Program:
SBIR
Phase:
Phase II
Contract:
W81XWH-10-C-0061
Agency Tracking Number:
O2-1083
Solicitation Year:
2009
Solicitation Topic Code:
OSD09-H06
Solicitation Number:
2009.3
Small Business Information
Advanced Brain Monitoring
2237 Faraday Ave, Suite 100, Carlsbad, CA, -
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
969842715
Principal Investigator:
Djordje Popovic
Director of Research
(760) 720-0099
dpopovic@b-alert.com
Business Contact:
Sandy Crow
VP of Government Contract
(760) 720-0099
scrow@b-alert.com
Research Institution:
Stub




Abstract
It is well known that the brain is the organ most sensitive to ischemia/hypoxia. Noninvasive continuous monitoring of cerebral blood flow autoregulation, cerebrovascular reactivity and related phenomena such as cerebral vasospams in combat casualties could guide clinicians/medics in adjusting the strategy of resuscitation and acute care, and therefore contribute to a substantially improved survival and functional outcome. In Phase I we developed a small (3.5 x 2.5 x 0.7 in), light-weight (<4oz), battery powered and hand-portable 3-channel monitor that combines electro- and rheoencephalography (EEG and REG). While REG detects changes in cerebral vascular bed, EEG can be used to detect post-traumatic non-convulsive seizures or reversible breakdown of the synaptic transmission. The monitor can transfer the data in real time via either a Bluetooth link or standard USB connection. The monitor also has sufficient memory to store the raw data from>300 hours of recording. In Phase II we propose to ruggedize the Phase I monitor so to make it truly field-deployable, and to in part directly organize, and in part support, a number of animal and human studies (including a study on TBI patients) that should provide evidence of the efficacy of the monitor.

* information listed above is at the time of submission.

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