Neuromonitoring of Traumatic Brain/blast Injury

Award Information
Agency: Department of Defense
Branch: Army
Contract: W81XWH-10-C-0061
Agency Tracking Number: O2-1083
Amount: $749,994.00
Phase: Phase II
Program: SBIR
Awards Year: 2011
Solicitation Year: 2009
Solicitation Topic Code: OSD09-H06
Solicitation Number: 2009.3
Small Business Information
Advanced Brain Monitoring
2237 Faraday Ave, Suite 100, Carlsbad, CA, -
DUNS: 969842715
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Djordje Popovic
 Director of Research
 (760) 720-0099
Business Contact
 Sandy Crow
Title: VP of Government Contract
Phone: (760) 720-0099
Research Institution
It is well known that the brain is the organ most sensitive to ischemia/hypoxia. Noninvasive continuous monitoring of cerebral blood flow autoregulation, cerebrovascular reactivity and related phenomena such as cerebral vasospams in combat casualties could guide clinicians/medics in adjusting the strategy of resuscitation and acute care, and therefore contribute to a substantially improved survival and functional outcome. In Phase I we developed a small (3.5 x 2.5 x 0.7 in), light-weight (<4oz), battery powered and hand-portable 3-channel monitor that combines electro- and rheoencephalography (EEG and REG). While REG detects changes in cerebral vascular bed, EEG can be used to detect post-traumatic non-convulsive seizures or reversible breakdown of the synaptic transmission. The monitor can transfer the data in real time via either a Bluetooth link or standard USB connection. The monitor also has sufficient memory to store the raw data from>300 hours of recording. In Phase II we propose to ruggedize the Phase I monitor so to make it truly field-deployable, and to in part directly organize, and in part support, a number of animal and human studies (including a study on TBI patients) that should provide evidence of the efficacy of the monitor.

* information listed above is at the time of submission.

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