Rickettsiae Detection Dipstick

Award Information
Agency: Department of Defense
Branch: Army
Contract: W81XWH-10-C-0011
Agency Tracking Number: A2-4346
Amount: $779,988.00
Phase: Phase II
Program: SBIR
Awards Year: 2011
Solitcitation Year: 2009
Solitcitation Topic Code: A09-152
Solitcitation Number: 2009.3
Small Business Information
Physical Optics Corporation
Applied Technologies Division, 20600 Gramercy Place, Bldg. 100, Torrance, CA, -
Duns: 153865951
Hubzone Owned: N
Woman Owned: Y
Socially and Economically Disadvantaged: N
Principal Investigator
 Gregory Zeltser
 Principal Scientist
 (310) 320-3088
 psproposals@poc.com
Business Contact
 Gordon Drew
Title: Chief Financial Officer
Phone: (310) 320-3088
Email: gedrew@poc.com
Research Institution
N/A
Abstract
To address the U.S. Army need for a hand-held, field-usable assay capable of diagnosing rickettsial disease in sick soldiers to aid early treatment with the appropriate antibiotic, Physical Optics Corporation (POC) proposes to complete the development of a new Rickettsiae Detection Dipstick (RDD). The RDD is a hand-held device based on a combination of lateral-flow immunochromatography technology and lab-on-chip principles. The RDD assay will rapidly (10 min) distinguish rickettsia antigens/pathogens in the spotted fever group (SFG) from typhus group (TG) in a blood sample. The RDD will be inexpensive, portable, and easy to use in a one-step protocol with at least 85% of the sensitivity and 85% of the specificity of current gold-standard assays. The device will use heat-stable reagents, have no special storage requirements, and require no power to operate. In Phase I POC demonstrated the feasibility of the RDD device by fabricating a prototype and demonstrating its capability to identify and differentiate inactivated rickettsia from SFG and TG spiked into porcine blood at concentrations

* information listed above is at the time of submission.

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