Rickettsiae Detection Dipstick

Award Information
Agency:
Department of Defense
Branch
Army
Amount:
$779,988.00
Award Year:
2011
Program:
SBIR
Phase:
Phase II
Contract:
W81XWH-10-C-0011
Agency Tracking Number:
A2-4346
Solicitation Year:
2009
Solicitation Topic Code:
A09-152
Solicitation Number:
2009.3
Small Business Information
Physical Optics Corporation
Applied Technologies Division, 20600 Gramercy Place, Bldg. 100, Torrance, CA, -
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
Y
Duns:
153865951
Principal Investigator:
Gregory Zeltser
Principal Scientist
(310) 320-3088
psproposals@poc.com
Business Contact:
Gordon Drew
Chief Financial Officer
(310) 320-3088
gedrew@poc.com
Research Institution:
n/a
Abstract
To address the U.S. Army need for a hand-held, field-usable assay capable of diagnosing rickettsial disease in sick soldiers to aid early treatment with the appropriate antibiotic, Physical Optics Corporation (POC) proposes to complete the development of a new Rickettsiae Detection Dipstick (RDD). The RDD is a hand-held device based on a combination of lateral-flow immunochromatography technology and lab-on-chip principles. The RDD assay will rapidly (10 min) distinguish rickettsia antigens/pathogens in the spotted fever group (SFG) from typhus group (TG) in a blood sample. The RDD will be inexpensive, portable, and easy to use in a one-step protocol with at least 85% of the sensitivity and 85% of the specificity of current gold-standard assays. The device will use heat-stable reagents, have no special storage requirements, and require no power to operate. In Phase I POC demonstrated the feasibility of the RDD device by fabricating a prototype and demonstrating its capability to identify and differentiate inactivated rickettsia from SFG and TG spiked into porcine blood at concentrations

* information listed above is at the time of submission.

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