An Electrochemical, Point-of-Care Detector for Reagent-free, In-situ Diagnostics of Pathogens

Award Information
Agency:
National Aeronautics and Space Administration
Branch
n/a
Amount:
$124,923.00
Award Year:
2012
Program:
STTR
Phase:
Phase I
Contract:
NNX12CG02P
Agency Tracking Number:
110060
Solicitation Year:
2011
Solicitation Topic Code:
T1.02
Solicitation Number:
n/a
Small Business Information
CFD Research Corporation
AL, Huntsville, AL, 35805-1944
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
Y
Duns:
185169620
Principal Investigator:
Jianjun Wei
Principal Investigator
(256) 327-0672
proposals-contracts@cfdrc.com
Business Contact:
Silvia Harvey
Business Official
(256) 726-4858
sxh@cfdrc.com
Research Institution:
Marilyn Haapapuro
Marilyn Haapapuro
1400 Townsend Drive
Houghton, MI, 49931-1295
() -
Domestic nonprofit research organization
Abstract
For long-term exploratory space travel, there will be a critical need for in-situ diagnosis and assessment of biological specimens from symptomatic astronauts, especially, disease pathogens (virus, bacterium, or fungus) and microbial contaminants. Hence, a real-time, non-culture-based microbial detection, identification and quantification system for on-flight monitoring and evaluation of pathogens from astronauts, or the space environment, is strongly desired. The success of such diagnostic tasks critically depends upon the degree of automation and reliability of such trace level detection. To meet this need, we propose to develop a novel miniaturized, point-of-care (POC) detector for reagent-free, no-culturing, in-situ diagnostics of disease pathogens. The envisioned device will be compact, lightweight, fully integrated and automated (requiring minimum human intervention), and highly cost-effective and power-efficient. In Phase I, we will develop a new type of electrochemical molecules and fabricate solid electrode-based probe for in-vitro demonstration of accurate and effective signal transduction of selective binding of pathogenic cells to the electrode as proof-of-principle. In Phase II, the electrode probe will be optimized to increase specificity, sensitivity, stability, and the response to regular biological samples. Finally, the sensor will be integrated with a compact handheld instrument for data collection, analysis and processing and interfacing with existing NASA space instrumentation for both terrestrial and microgravity environments evaluation.

* information listed above is at the time of submission.

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