Substrate-Enhanced Micro Laser Desorption Ionization Mass Spectrometry

Award Information
Agency: National Aeronautics and Space Administration
Branch: N/A
Contract: NNX12CG18P
Agency Tracking Number: 110211
Amount: $125,000.00
Phase: Phase I
Program: STTR
Awards Year: 2012
Solicitation Year: 2011
Solicitation Topic Code: T5.01
Solicitation Number: N/A
Small Business Information
Aerodyne Research, Inc.
45 Manning Road, Billerica, MA, -
DUNS: 030817290
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Joda Wormhoudt
 Principal Investigator
 (978) 932-0229
 jody@aerodyne.com
Business Contact
 Cameron Martin
Title: Marketing Administrator
Phone: (978) 663-9500
Email: cmartin@aerodyne.com
Research Institution
 University of Massachusetts Amherst
 Jennifer Donais
 Research Administration Bldg, 70 Butterfield Terrace
Amherst, MA, 01003-9242
 () -
 Domestic nonprofit research organization
Abstract
Aerodyne Research, Inc. and the University of Massachusetts at Amherst will collaborate to develop laser desorption ionization (LDI) mass spectrometric analysis of organic analytes of interest in planetary exploration, based on microchip laser illumination. The key advantage of microchip lasers in this application is their much smaller size and weight than lasers used to date for LDI. These lasers have not been used because they have much smaller pulse energies than currently used LDI lasers. We propose to investigate the use of LDI substrates with special properties that include lowering the laser fluence required for LDI. Our Phase I candidate substrate will be gold nanoparticles coated with functionalized monolayers. Coated nanoparticles have been shown to have significant advantages in LDI applications, including selectivity of analyte adsorption, and enhancement of desorption via surface plasmon resonance (SPR) effects.

* information listed above is at the time of submission.

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