Substrate-Enhanced Micro Laser Desorption Ionization Mass Spectrometry

Award Information
Agency:
National Aeronautics and Space Administration
Branch
n/a
Amount:
$125,000.00
Award Year:
2012
Program:
STTR
Phase:
Phase I
Contract:
NNX12CG18P
Award Id:
n/a
Agency Tracking Number:
110211
Solicitation Year:
2011
Solicitation Topic Code:
T5.01
Solicitation Number:
n/a
Small Business Information
45 Manning Road, Billerica, MA, -
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
030817290
Principal Investigator:
JodaWormhoudt
Principal Investigator
(978) 932-0229
jody@aerodyne.com
Business Contact:
CameronMartin
Marketing Administrator
(978) 663-9500
cmartin@aerodyne.com
Research Institute:
University of Massachusetts Amherst
Jennifer Donais
Research Administration Bldg, 70 Butterfield Terrace
Amherst, MA, 01003-9242
() -

Abstract
Aerodyne Research, Inc. and the University of Massachusetts at Amherst will collaborate to develop laser desorption ionization (LDI) mass spectrometric analysis of organic analytes of interest in planetary exploration, based on microchip laser illumination. The key advantage of microchip lasers in this application is their much smaller size and weight than lasers used to date for LDI. These lasers have not been used because they have much smaller pulse energies than currently used LDI lasers. We propose to investigate the use of LDI substrates with special properties that include lowering the laser fluence required for LDI. Our Phase I candidate substrate will be gold nanoparticles coated with functionalized monolayers. Coated nanoparticles have been shown to have significant advantages in LDI applications, including selectivity of analyte adsorption, and enhancement of desorption via surface plasmon resonance (SPR) effects.

* information listed above is at the time of submission.

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