Non-invasive Continuous Hemodynamic Monitor

Award Information
Agency: Department of Defense
Branch: Defense Advanced Research Projects Agency
Contract: W31P4Q-12-C-0192
Agency Tracking Number: D12A-003-0032
Amount: $99,997.00
Phase: Phase I
Program: STTR
Awards Year: 2012
Solicitation Year: 2012
Solicitation Topic Code: SB12A-003
Solicitation Number: 2012.A
Small Business Information
Radiation Monitoring Devices, Inc.
MA, Watertown, MA, 02472-4699
DUNS: 073804411
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 David Wolf
 Group Leader, Optics and Photonics
 (617) 668-6800
 DWolf@RMDInc.com
Business Contact
 Joanne Gladstone
Title: Vice President
Phone: (617) 668-6800
Email: JGladstone@RMDInc.com
Research Institution
 Mayo Clinic
 Michael J Joyner, M.D.
 200 First Street SW
Rochester, MN, 55905-
 (507) 255-7197
 Nonprofit college or university
Abstract
Emergency departments, trauma centers, and military field physicians have a critical need for a simple, easy-to-use, and reliable method of monitoring the onset of hemorrhagic shock that is able to predict onset during the compensatory phase, before syncope and cardiac collapse signaled by a rapid drop in blood pressure. In collaboration with Dr. Michael Joyner"s laboratory at the Mayo Clinic, RMD is developing a near infrared capillary blood flow measurement system (CapFlowTM), based upon diffuse correlation spectroscopy (DCS), that will predict shock onset. In its final configuration this will be a small innocuous patch that wirelessly communicates with a remote station and noninvasively monitors physiological status, assessing soldier health either in the field or in an emergency/ triage setting. Using the lower body negative pressure model in humans in Phase I we will: 1. provide proof-of-principle of the value of using DCS blood flow measurement as a shock predictor; 2. determine the depth beneath the skin where blood flow correlates most strongly with cardiac output; and 3. determine the"best"site for attaching the DCS probe to the skin.

* information listed above is at the time of submission.

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