NIR Dyes for Enhanced Analyte Sensing In Vivo

Award Information
Agency:
Department of Defense
Branch
Defense Advanced Research Projects Agency
Amount:
$99,817.00
Award Year:
2012
Program:
STTR
Phase:
Phase I
Contract:
W31P4Q-12-C-0205
Award Id:
n/a
Agency Tracking Number:
D12A-003-0052
Solicitation Year:
2012
Solicitation Topic Code:
SB12A-003
Solicitation Number:
2012.A
Small Business Information
1219 18th St, San Francisco, CA, 94107-
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
Y
Duns:
830219338
Principal Investigator:
NatalieWisniewski
Chief Scientific Officer
(415) 205-9176
Natalie_Ann_Wisniewski@yahoo.com
Business Contact:
WilliamMcMillan
Chief Executive Officer
(408) 499-9447
billmcmillan23@gmail.com
Research Institute:
University of Washington
Buddy D Ratner
3720 15th Ave NE
Box 355061
Seattle, WA, 98195-5061
(206) 685-1005

Abstract
Continuous monitoring of body chemistries for metabolic monitoring, monitoring concentration of biothreats, early detection of sickness, and stress monitoring has the potential to enhance warrior performance. Currently available sensors are inaccurate and have short lifetimes, primarily due to the body"s foreign body response (FBR) to implanted materials. PROFUSA"s tissue-integrating sensor platform was shown to overcome the FBR during long-term animal studies in a recently completed DARPA seedling project. Changes in lifetime and intensity of luminescent sensing nanospheres within the sensor reflect fluctuating analyte concentrations, and are monitored optically through the skin. Therefore, efficient light propagation through the skin is critical, necessitating stable dyes in the optical window of the skin. In this Phase I STTR, PROFUSA proposes to synthesize a stable luminescent dye with excitation and emission spectra in the NIR optical window of the skin to replace current dyes that are either prone to photobleaching or fall outside the optical window of the skin. The NIR dye will be incorporated into a functional glucose assay contained in PROFUSA"s proprietary scaffold and tested in vitro. Synthesis of the proposed dye will enable a platform in which many other molecules may be monitored though exchange of the recognition element (e.g. lactate).

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government