NIR Dyes for Enhanced Analyte Sensing In Vivo

Award Information
Agency: Department of Defense
Branch: Defense Advanced Research Projects Agency
Contract: W31P4Q-12-C-0205
Agency Tracking Number: D12A-003-0052
Amount: $99,817.00
Phase: Phase I
Program: STTR
Awards Year: 2012
Solicitation Year: 2012
Solicitation Topic Code: SB12A-003
Solicitation Number: 2012.A
Small Business Information
1219 18th St, San Francisco, CA, 94107-
DUNS: 830219338
HUBZone Owned: N
Woman Owned: Y
Socially and Economically Disadvantaged: N
Principal Investigator
 Natalie Wisniewski
 Chief Scientific Officer
 (415) 205-9176
Business Contact
 William McMillan
Title: Chief Executive Officer
Phone: (408) 499-9447
Research Institution
 University of Washington
 Buddy D Ratner
 3720 15th Ave NE
Box 355061
Seattle, WA, 98195-5061
 (206) 685-1005
 Nonprofit college or university
Continuous monitoring of body chemistries for metabolic monitoring, monitoring concentration of biothreats, early detection of sickness, and stress monitoring has the potential to enhance warrior performance. Currently available sensors are inaccurate and have short lifetimes, primarily due to the body"s foreign body response (FBR) to implanted materials. PROFUSA"s tissue-integrating sensor platform was shown to overcome the FBR during long-term animal studies in a recently completed DARPA seedling project. Changes in lifetime and intensity of luminescent sensing nanospheres within the sensor reflect fluctuating analyte concentrations, and are monitored optically through the skin. Therefore, efficient light propagation through the skin is critical, necessitating stable dyes in the optical window of the skin. In this Phase I STTR, PROFUSA proposes to synthesize a stable luminescent dye with excitation and emission spectra in the NIR optical window of the skin to replace current dyes that are either prone to photobleaching or fall outside the optical window of the skin. The NIR dye will be incorporated into a functional glucose assay contained in PROFUSA"s proprietary scaffold and tested in vitro. Synthesis of the proposed dye will enable a platform in which many other molecules may be monitored though exchange of the recognition element (e.g. lactate).

* Information listed above is at the time of submission. *

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