Nanosensor Switches for Detection of Toxins, Pathogens, and Small Molecules

Award Information
Agency: Department of Defense
Branch: Air Force
Contract: FA8650-12-M-5123
Agency Tracking Number: F11B-T09-0134
Amount: $99,967.00
Phase: Phase I
Program: STTR
Awards Year: 2012
Solicitation Year: 2011
Solicitation Topic Code: AF11-BT09
Solicitation Number: 2011.B
Small Business Information
100 Intrepid Lane, Suite 1, Syracuse, NY, 13205-
DUNS: 138843722
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Mark McPike
 CSO
 (315) 299-7167
 mpmcpike@aptamatrix.com
Business Contact
 Mark McPike
Title: CSO
Phone: (315) 299-7167
Email: mpmcpike@aptamatrix.com
Research Institution
 Syracuse University
 Rebecca Bader
 Biomedical&Chemical Engineer
Syracuse Biomaterials Inst.
Syracuse, NY, 13244-3244
 (315) 443-9709
 Nonprofit college or university
Abstract
ABSTRACT: This phase I STTR project is a proof of concept study for developing near real-time, nanoparticle based sensors that detect the presence of specified toxins, pathogens, proteins, metabolites and small molecules. The specificity and sensitivity of this"nanosensor"is imparted by aptamer recognition that is engineered into a novel, patented technology we termed as an Alloswitch. These Alloswitch sensors will be embedded in nanoparticles to create a"nanosensor"that are capable of long term storage, easy to administer to patients, and facilitate entry and uptake by cells. BENEFIT: There is a clear need for detection of bio-terror agents and new options for treatment of affected military and civilian personnel. There are also military and civilian needs for rapid diagnostics in bodily fluids and cells. Our nanosensor platform will enable rapid detection of targeted microorganisms, viruses, proteins, and metabolites, and also provide therapeutic options. Detection can be made in bodily fluids or specifically chosen cell types. Success in these applications will be of tremendous commercial and societal value.

* Information listed above is at the time of submission. *

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