Design Automation Software for DNA-Based Nano-Sensor Architectures

Award Information
Agency: Department of Defense
Branch: Army
Contract: W911NF-12-C-0060
Agency Tracking Number: O2-1274
Amount: $749,976.00
Phase: Phase II
Program: STTR
Awards Year: 2012
Solicitation Year: 2010
Solicitation Topic Code: OSD10-T003
Solicitation Number: 2010.B
Small Business Information
6525 Belcrest Rd, Hyattsville, MD, -
DUNS: 788153166
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Raymond Peterson
 Chief Science Officer
 (301) 683-2118
 peterson@celadonlabs.com
Business Contact
 Lawrence Kessner
Title: Chief Executive Officer
Phone: (301) 683-2117
Email: lkessner@celadonlabs.com
Research Institution
 Univ of Rochester+Univ.of Maryland
 Tammie Martin
 518 Hylan Building
PO Box 270140
Rochester, NY, 14627-0140
 (585) 275-4031
 Nonprofit college or university
Abstract
A continuing and growing threat to US military personnel and civilians is exposure to toxic chemicals and pathogens. Useful detection systems exist, but it remains imperative to investigate new technologies that have the potential to significantly improve the cost, sensitivity, and size of sensor devices. A promising technology that may achieve these goals is DNA-based nono-sensors. In order for this technology to become viable, it needs automated assay design software. To achieve this, Celadon will collaborate with Dr. David Mathews, an expert in the computation of nucleic acid structures; and with Dr. Jason Kahn, an expert in dna structure and topology and nucleic acid thermodynamics. In Phase I, our team computed databates of optimal helices and loops; developed a heuristic algorithm that obviates the need to evaluate an entire structure; developed a new algorithm for design of psuedo knots, among other deliverables. In Phase II, we will nxnxnxnxnxnxnxnxn

* Information listed above is at the time of submission. *

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