Human Brown Adipocyte Transplantation and In Vivo Metabolic Characterization

Award Information
Agency:
Department of Defense
Branch
Army
Amount:
$749,692.00
Award Year:
2012
Program:
STTR
Phase:
Phase II
Contract:
W81XWH-11-C-0517
Award Id:
n/a
Agency Tracking Number:
A2-5081
Solicitation Year:
2011
Solicitation Topic Code:
A11a-T034
Solicitation Number:
2011.A
Small Business Information
770 Boylston Street #26G, Boston, MA, -
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
831412205
Principal Investigator:
Olivier Boss
Chief Scientific Officer
(617) 959-2322
oboss@energesispharma.com
Business Contact:
Brian Freeman
Chief Operating Officer
(617) 947-9773
bfreeman@energesispharma.com
Research Institute:
Boston University
Stephen R Farmer
Silvio Conte Building, K602
72 E. Concord Street
Boston, MA, 02118-
(617) 638-4186
Nonprofit college or university
Abstract
Obesity and its associated metabolic complications including diabetes are becoming increasingly prevalent in the general population as well as in military personnel. Brown adipose tissue (BAT) is a major site of energy expenditure through thermogenesis, which is mediated by the mitochondrial uncoupling protein-1 (UCP1). Studies in animals over the last 30 years as well as recent data in humans strongly suggest that overweight and obese individuals have a low amount of BAT, and that increasing BAT by about 50 grams in obese patients would induce strong weight loss and improve metabolic status (including glucose metabolism, lipid profiles, and cardiovascular risk). The proposed studies aim to develop a prototype system for the transplantation of autologous brown adipocytes. We intend to demonstrate that a readily generated population of human brown adipocytes can be transplanted into an animal model of human obesity and insulin resistance, and that these cells can survive and produce significant improvements in glycemic control and body composition (e.g., body weight, fat mass).

* information listed above is at the time of submission.

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