Robotic, MEMS-based Multi Utility Sample Preparation Instrument for ISS Biological Workstation

Award Information
Agency:
National Aeronautics and Space Administration
Branch
n/a
Amount:
$125,000.00
Award Year:
2012
Program:
SBIR
Phase:
Phase I
Contract:
NNX12CE75P
Agency Tracking Number:
115704
Solicitation Year:
2011
Solicitation Topic Code:
O3.02
Solicitation Number:
n/a
Small Business Information
Microsonic Systems Inc.
76 Bonaventura Drive, San Jose, CA, 95134-2123
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
179898635
Principal Investigator:
Vibhu Vivek
Principal Investigator
(408) 844-4986
vibhu.vivek@microsonics.com
Business Contact:
Daniel C Holley
Business Official
(408) 499-3149
dcholley2004@yahoo.com
Research Institution:
Stub




Abstract
This project will develop a multi-functional, automated sample preparation instrument for biological wet-lab workstations on the ISS. The instrument is based on a transducer technology developed by Microsonics Systems; BLU (Bulk Lateral Ultrasonic). BLU works by using a MEMS based transducer, which when excited with RF power generates ultrasonic waves. Since these waves when focused by an Fresnel Annular Sector Actuator (FASA) have a very high level of lateral ultrasonic thrust, the coupling of them into a well causes a lateral mixing vortex. Banks of these transducers are contained in a multi-station, robotic, compact instrument. The instrument utilizes a centrifuge to produce a gravity vector into tubes containing samples which are ultrasonically coupled to the FASA transducer. The electrical energy is inductively coupled into the transducer which generate BLU energy for fluid processing in the sample tube. Samples placed into the instrument will be directed to the proper transducer set (correct BLU power), for 1) cell/tissue lysis, 2) cell fractionation, 3) Sample mixing and compound solubilization 4) DNA shearing for microbiological applications, e.g., PCR, micro array analysis, other analysis (TBD).

* information listed above is at the time of submission.

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