Robotic, MEMS-based Multi Utility Sample Preparation Instrument for ISS Biological Workstation

Award Information
Agency: National Aeronautics and Space Administration
Branch: N/A
Contract: NNX12CE75P
Agency Tracking Number: 115704
Amount: $125,000.00
Phase: Phase I
Program: SBIR
Awards Year: 2012
Solicitation Year: 2011
Solicitation Topic Code: O3.02
Solicitation Number: N/A
Small Business Information
76 Bonaventura Drive, San Jose, CA, 95134-2123
DUNS: 179898635
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Vibhu Vivek
 Principal Investigator
 (408) 844-4986
 vibhu.vivek@microsonics.com
Business Contact
 Daniel C Holley
Title: Business Official
Phone: (408) 499-3149
Email: dcholley2004@yahoo.com
Research Institution
 Stub
Abstract
This project will develop a multi-functional, automated sample preparation instrument for biological wet-lab workstations on the ISS. The instrument is based on a transducer technology developed by Microsonics Systems; BLU (Bulk Lateral Ultrasonic). BLU works by using a MEMS based transducer, which when excited with RF power generates ultrasonic waves. Since these waves when focused by an Fresnel Annular Sector Actuator (FASA) have a very high level of lateral ultrasonic thrust, the coupling of them into a well causes a lateral mixing vortex. Banks of these transducers are contained in a multi-station, robotic, compact instrument. The instrument utilizes a centrifuge to produce a gravity vector into tubes containing samples which are ultrasonically coupled to the FASA transducer. The electrical energy is inductively coupled into the transducer which generate BLU energy for fluid processing in the sample tube. Samples placed into the instrument will be directed to the proper transducer set (correct BLU power), for 1) cell/tissue lysis, 2) cell fractionation, 3) Sample mixing and compound solubilization 4) DNA shearing for microbiological applications, e.g., PCR, micro array analysis, other analysis (TBD).

* Information listed above is at the time of submission. *

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