Subcellular imaging of biochemical processes within human retina

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$1,865,561.00
Award Year:
2012
Program:
SBIR
Phase:
Phase II
Contract:
9R44AG043645-02
Award Id:
n/a
Agency Tracking Number:
R44AG043645
Solicitation Year:
2012
Solicitation Topic Code:
NIA
Solicitation Number:
PA11-096
Small Business Information
11000 CEDAR AVE, STE 260, CLEVELAND, OH, -
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
785024089
Principal Investigator:
GRAZYNAPALCZEWSKA
(440) 319-7616
gpalczewska@polgenixinc.com
Business Contact:
VIDATRIPODO
(216) 368-5996
vtripodo@polgenixinc.com
Research Institute:
Stub




Abstract
DESCRIPTION (provided by applicant): Polgenix, Inc. is developing an imaging instrument, the 2-photon ophthalmoscope , or 2PO , with the capability for non-invasive, repetitive and high-resolution imaging of biochemical processes within human retina.This device will allow early detection of age- and disease- related changes in the eye, long before pathological manifestations of retinal disease become discernable by existing methods. Such real-time retinal imaging will also be critical for evaluationof various therapies for retinal pathology. Thus, patients susceptible to retinal disease could be diagnosed with 2PO and treated well before vision loss occurs. Once developed, the instrument will be used initially for ophthalmic drug screening and establishing objective biomarkers for retinal disease in animal models. Then it will be employed for clinical trials and ultimately for monitoring retinal health and the impact of therapy in patients. Early application of the device toward the development of effective ophthalmic therapies and clinical diagnosis will be leveraged through collaboration with experts in biochemical processes in the eye and high-resolution adaptive optics ophthalmic imaging from Case Western Reserve University and the University of Rochester, respectively. PUBLIC HEALTH RELEVANCE: We seek to develop a novel instrument for noninvasive imaging of the back of the eye with sub-cellular resolution. The instrument will visualize and quantify the age or disease related changes in the biochemical processes within human retina. Our goal is to further understanding of the biochemistry of vision and to enable rapid evaluation of the impact of therapeutic interventions aimed at retinal diseases at the earliest stages, before retina is damaged and vision is irreparably diminished.

* information listed above is at the time of submission.

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