Off-the-shelf Dental Regeneration Technologies

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$665,015.00
Award Year:
2012
Program:
SBIR
Phase:
Phase II
Contract:
2R44DE019748-02A1
Award Id:
n/a
Agency Tracking Number:
R44DE019748
Solicitation Year:
2012
Solicitation Topic Code:
NIDCR
Solicitation Number:
PA11-096
Small Business Information
560 Sylvan Ave STE 3160, Englewood Cliffs, NJ, -
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
809512853
Principal Investigator:
SUSAN FU
(201) 560-7181
sfu868@gmail.com
Business Contact:
SUSAN FU
(201) 560-7312
sfu868@gmail.com
Research Institute:
Stub




Abstract
DESCRIPTION (provided by applicant): Dentin forms the bulk of the tooth and is covered by enamel in the crown of the tooth and cementum in the root. When dental caries breaks down enamel and involves the dentin, the patient experiences pain and thermal sensitivity. The acute phase of dental pulp infection is typically associated with excruciating pain, and if not properly managed, can lead to peri-apical infection, tooth loss, facial infection and even systemic infections such as endocardiomyotis. Currentdental treatments for tooth decay rely on surgical removal of decayed enamel and dentin by dental instruments and filling of the prepared cavity with artificial materials including amalgam and composite resin. However, current restorative dental treatmentsby artificial fillers have finite service life and can fail unpredictably. Tooth fracture and secondary infections are among some of the well documented complications of current dental and endodontic treatments. Treatment options are further limited for deciduous teeth and young permanent teeth. We have discovered that dentin-like tissues can regenerate by bioactive scaffold formulations in our SBIR Phase I related work. The overall goal of this SBIR/Phase-2 proposal is to identify and prepare efficaciousand safe bioactive scaffold formulations for the regeneration of dentin-like tissues. This SBIR-Phase 2 represents essential intermediate funding to advance our technologies to the next stage of commercialization and eventually into a product that can ultimately regenerate dentin in patients who suffer from dental pain, trauma and infections. PUBLIC HEALTH RELEVANCE: Dental caries breaks down enamel and dentin, causing pain and infections. Current dental treatments for tooth decay rely on surgical removal of decayed enamel and dentin and filling of the prepared cavity with artificial materials. We have designed a technology to regenerate dentin-like structures that may be ultimately applicable to patients who suffer from dental pain, trauma and infections.

* information listed above is at the time of submission.

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